结肠癌根治术后化疗联合自体级联诱发免疫细胞治疗对患者预后的影响

Effect of chemotherapy after radical surgery combined with cascade primed immune cell therapy on colon cancer patients' prognosis

目的：研究结肠癌根治术后化疗联合自体级联诱发免疫细胞治疗对患者预后的影响。方法：选择2012年5月~2014年12月期间在我院接受结肠癌根治术辅助术后化疗的78例结肠癌患者进行治疗,随机分为两组,联合治疗组进行化疗联合自体级联诱发免疫细胞治疗,单纯化疗组进行FOLFOX方案化疗,测定血清中肿瘤标志物含量、血管新生分子含量以及外周血中红细胞免疫功能指标。结果：联合治疗组患者血清中肿瘤标志物CCSA-2、CCSA-3、CCSA-4、PTN、NGAL、sMICA以及血管新生分子VEGF、FGF10、sICAM-1、sVCAM-1、Musashi1、Dkk1的含量低于常规化疗组（均P〈0.05）;联合治疗组患者外周血中CR1、CR3、CD58、CD59比例以及红细胞C3b受体花环形成率、免疫复合物花环形成率均显著高于常规化疗组（均P〈0.05）。结论：结肠癌根治术后化疗联合自体级联诱发免疫细胞治疗有助于杀伤肿瘤细胞、抑制血管新生,同时增强红细胞免疫功能,对结肠癌根治术的预后具有改善作用。

Objective：To study the effect of chemotherapy after radical surgery combined with cascade primed immune cell therapy on colon cancer patients＇prognosis.Methods：A total of 78 cases with colon cancer who received radical surgery of colon cancer assisted by postoperative chemotherapy in our hospital from May 2012 to December 2014 were selected for treat-ment and randomly divided into two groups,combined treatment group receiving chemotherapy combined with cascade primed immune cell therapy,simple chemotherapy group receiving FOLFOX chemotherapy,and then serum tumor marker contentsnbsp;and angiogenesis molecule contents as well as red blood cell immune function indicators in peripheral blood were detected.Re-sults：Serum tumor markers CCSA-2,CCSA-3,CCSA-4,PTN,NGAL and sMICA as well as angiogenesis molecules VEGF, FGF10,sICAM-1,sVCAM-1,Musashi1 and Dkk1 contents of combined treatment group were lower than those of convention-al chemotherapy group;the proportion of CR1,CR3,CD58 and CD59 as well as the rosette formation rates of red blood cell C3b receptor and immune complex in peripheral blood of combined treatment group were significantly higher than those of con-ventional chemotherapy group.Conclusion：Chemotherapy after radical surgery combined with cascade primed immune cell therapy helps to kill tumor cells and inhibit angiogenesis while enhance red blood cell immune function,and it can improve the prognosis of radical surgery of colon cancer.