阿托伐他汀联合脑心通胶囊治疗脑梗死患者颈动脉粥样硬化的临床分析

Effect of atorvastatin in combined with Naoxintong capsue on carotid atherosclerosis in patients with cerebral infarction

目的：探讨阿托伐他汀联合脑心通胶囊对脑梗死患者颈动脉粥样硬化（CAS）的临床疗效。方法：分析云南省玉溪市人民医院2015年2月~2016年2月收治的120例脑梗死合并CAS患者的临床资料,随机分为观察组与对照组;对照组睡前拜阿司匹林100mg/次顿服,晚餐时阿托伐他汀20mg/次顿服,观察组在对照组基础上口服步长脑心通胶囊4粒/次,3次/d,两组用药疗程均为6个月;全自动生化仪检测血清总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白（HDL-C）、低密度脂蛋白（LDL-C）,免疫比浊法检测血清C反应蛋白（CRP）水平,彩色多普勒超声诊断仪检测颈动脉内膜-中层厚度（IMT）及斑块总面积。结果：治疗6个月后,两组TC、TG、LDL-C水平均降低,HDL-C升高,与治疗前比较有统计学意义（P〈0.05）,观察组各指标改善情况优于对照组,差异有统计学意义（P〈0.05）;治疗6个月后,两组CRP水平均降低,与治疗前比较差异有统计学意义（P〈0.05）,观察组降低优于对照组,差异有统计学意义（P〈0.05）;治疗6个月后,两组IMT、斑块面积均减小,与治疗前比较差异有统计学意义（P〈0.05）,观察组优于对照组,差异有统计学意义（P〈0.05）。结论：阿托伐他汀、脑心通胶囊联合应用,可有效调节脑梗死CAS患者血脂水平,降低炎症反应,改善动脉粥样硬化症状,降低脑梗死的发生与复发,值得临床推广。

Objective：To explore the clinical efficacy of atorvastatin in combined with Naoxintong capsue in the treat-ment of carotid atherosclerosis （CAS）in patients with cerebral infarction.Methods：A total of 120 patients with cerebral infarc-tion merged with CAS who were admitted in our hospital from February,201 5 to February,201 6 were included in the study and randomized into the observation group and the control group.The patients in the control group were given bayaspirin, 100mg/time,before sleep,and atorvastatin,20 mg/time,at dinner.On this basis,the patients in the observation group were given Buchang Naoxintong capuse,4 capusles/time,3 times/d.Six-month treatment was regarded as one course.The full au-tomatic biochemical analyzer was used to the serum TC,TG,HDL-C,and LDL-C levels.The immunoturbidimetric assay was used to detect the serum CRP level.The color Doppler ultrasonic diagnosis apparatus was used to detect IMT and the plaque ar-ea.Results：After 6-month treatment,the levels of TC,TG,and LDL-C in the two groups were significantly reduced,while HDL-C was significantly elevated when compared with before treatment （P 〈0.05）.The improvement of various indicators in the observation was significantly superior to that in the control group （P 〈0.05）.After 6-month treatment,CRP level in the two groups was significantly reduced when compared with before treatment （P 〈0.05）,and the reduced degree in the observa-tion group was significantly superior to that in the control group （P 〈0.05）.After 6-month treatment,IMT and the plaque ar-ea in the two groups were significantly reduced when compared with before treatment （P 〈0.05）,and the reduced degree in the observation group was significantly superior to that in the control group （P 〈0.05）.Conclusions：The combined application of atorvastatin and Naoxintong capsule in the treatment of CAS in patients with cerebral infarction can effectively regulate the ser-um lipid level,reduce the inflammatory reaction,improve the atherosclerotic symptoms,and reduce the occurrence and recur-rence of cerebral infarction;therefore,it deserves to be widely recommended in the clinic.