摘要
结果显示安定能抑制大鼠血浆、红细胞、纹状体和膈肌胆碱酯酶活性，此作用呈浓度增高而增强的趋势。还证实安定是真性胆碱酯酶的可逆性抑制剂，及在相同浓度时对红细胞膜有稳定作用；文中初步探讨了安定的这些作用在有机磷中毒的治疗中所起的作用。
The results confirmed that
diazepam inhibits the
cholinesterase in rat serum,red cell,corpus striatum and diaphragm in
vitro,that the higher the diazepam concentration,the stronger the
cholinesterase inhibition,and that diazepam is a reversible inhibitor
to acetylcholinesterase and diazepam has a stabilizing action on red
cell membranes.The role of these effects of diazepam in the treatment
of organic phosphate poisoning is discussed
关键词
安定
胆碱酯酶
有机磷
膜稳定性
Diazepam
Cholinesterase
Organic phosphate
Membrane stabiliy present
Address:Department of Pharmacology,Institute Materia Medica,Chinese
Academy of Medical Sciences,Beijing 100050
