基础胰岛素与预混胰岛素治疗2型糖尿病的临床比较

Clinical Comparison of Basal Insulin and Premixed Insulin in the Treatment of Type 2 Diabetes Mellitus

目的:探讨基础胰岛素与预混胰岛素治疗2型糖尿病的临床疗效。方法:选择2014年8月到2015年2月在广安门医院南区内分泌科住院2型糖尿病患者实验对象,被随机分配到每天两次预混门冬胰岛素30(PM-2)或每日一次甘精胰岛素加主餐前门冬胰岛素注射(G+1),比较两组的疗效。结果:基础胰岛素加一个餐时注射和预混胰岛素治疗能够有效改善血糖控制,胰岛素用量和低血糖发生率及体重增加幅度上和患者依从性上G+1较PM-2表现好,在改善血糖控制上比每日两次预混胰岛素稍差。结论:两种胰岛素治疗方法均较好改善了2型糖尿病血糖控制;预混胰岛素比甘精胰岛素联合速效治疗引发更多的低血糖症状;甘精胰岛素联合速效胰岛素与预混胰岛素一样有效。

Objective: To investigate the clinical effect of basal insulin and premixed insulin in the treatment of type 2 diabetes mellitus.Methods:Select August 2014 to 2015 February in the Southern District of Guang An Men Hospital endocrinology hospitalization in patients with type 2 diabetes mellitus subjects,were randomly assigned to twice daily pre mixed insulin aspart 30 (PM-2) or once daily insulin glargine and before the main meal insulin aspart injection (G+1),compared with two groups of curative effect.Results:The basal insulin plus a bolus injection and premixed insulin therapy can improve glycemic control,G+1 compared with PM-2 performed better patient compliance on the amount of insulin and the incidence of hypoglycemia and weight gain magnitude and in improving blood sugar control somewhat less than twice daily premixed insulin.Conclusion:Both methods are better insulin therapy improves glycemic control in type 2 diabetes.Than premixed insulin glargine combined with fast-acting treatment lead to more hypoglycemia.The therapeutic effect of Insulin Glargine combined fast-acting insulin and premixed insulin is the same.