对氯苯肼盐酸盐的合成

Synthesis of p-Cholorophenyluhydrazine Hydrochloride

以对氯苯胺、盐酸、亚硝酸钠等为原材料,经过重氮化、还原和水解过程合成对氯苯肼盐酸盐。结果表明,当n对氯苯胺∶n亚硝酸钠∶n盐酸∶n亚硫酸钠∶n氢氧化钠=1∶1.05∶2.5∶3∶2,滴加温度40℃,还原温度75℃,水解温度80℃,还原反应2h,水解反应2h,还原剂为混合还原剂时,对氯苯肼盐酸盐收率最高。

Applied p-chloroaniline, hydrochloric acid and sodium nitrite as raw materials, through diazotization, reduction and hydrolysis, p-cholorophenyluhydrazine hydrochloride was synthesized. The optimized reaction conditions were as followed: n(p-chloroaniline):n(sodium nitrite):n(hydrochloric acid):n(sodium sulfite):n(sodium hydroxide)=1:1.05:2.5:3:2,dropping temperature 40℃,reduction temperature75℃,hydrolysis 80℃,reduction reaction duration 2h,hydrolysis reaction duration 2h, the mixture of reducing agent. Under these conditions, the highest yield could be reached.