CK18、CK19与6项肿瘤标志物联合检测在恶性肿瘤诊断中的应用价值

Application value of combined detection of cytokeratin 18,cytokeratin 19 and 6 tumor markers in malignant tumor diagnose

目的:探讨CK18、CK19与6项肿瘤标志物联合检测在恶性肿瘤诊断中的应用价值。方法:将我院91例恶性肿瘤患者(肝癌、肺癌、乳腺癌)作为恶性组,73例良性疾病患者作为良性组,60例健康者作为对照组。采用化学发光法检测3组血清CK18、CK19水平,采用双抗体夹心化学发光检测法检测CEA、AFP、CA125、CA19-9、CA50、TSGF等6项肿瘤标志物水平,比较各组CK18、CK19与6项肿瘤标志物水平。结果:恶性组血清CK18、CK19水平与良性组和对照组相比显著升高,差异有统计学意义(P<0.05);恶性组6项肿瘤标志物其中五项CEA、CA125、CA19-9、CA50及TSGF的水平均显著高于良性组与对照组,差异有统计学意义(P<0.05);而恶性组血清AFP水平与良性组血清AFP水平比较,差异无统计学意义(P>0.05),但明显高于对照组血清AFP水平,差异有统计学意义(P<0.05);恶性组CK18、CK19与6项肿瘤标志物联合检测总阳性率较CK18、CK19联合检测及6项肿瘤标志物联合检测的阳性率明显更高,差异有统计学意义(P<0.05)。结论:CK18、CK19与6项肿瘤标志物CEA、AFP、CA125、CA19-9、CA50、TSGF进行联合检测对恶性肿瘤辅助诊断有较高临床应用价值,值得临床上进行推广。

Objective:To investigate the application value of combined detection of cytokeratin 18,cytokeratin 19 and 6tumor markers in malignant tumor diagnose.Methods:Malignant tumor patients(liver cancer,lung cancer,breast cancer)were regarded as malignant group(91cases),benign disease patients were regarded as benign group(73cases),and 60 healthy cases were regarded as control group.The levels of cytokeratin 18,cytokeratin 19 and 6tumor markers(CEA,AFP,CA125,CA19-9,CA50,TSGF)were tested and compared.Results:In the malignant group,the levels of cytokeratin 18,cytokeratin 19 were significantly higher than that in the benign group and control group(P<0.05);In the malignant group,the levels of 5tumor markers(CEA,CA125,CA19-9,CA50,TSGF)were significantly higher than that in the benign group andcontrol group(P<0.05),the level of AFP between the malignant group and benign group had no significant difference(P>0.05),the level of AFP was increased significantly compared with control group(P<0.05);In the malignant group,the positive rate of combined detection of cytokeratin 18,cytokeratin 19 and 6tumor markers was significantly higher than that of the combined detection of cytokeratin 18,cytokeratin 19 or combined detection of 6tumor markers(P<0.05).Conclusion:The combined detection of cytokeratin 18,cytokeratin 19 and 6tumor markers(CEA,AFP,CA125,CA19-9,CA50,TSGF)has a high application value in malignant tumor diagnose,and deserve the clinical expansion.