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高同型半胱氨酸血症与脑小血管病的研究进展 被引量：6

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摘要 同型半胱氨酸（homocysteine,Hcy）又名高半胱氨酸,是一种含巯基氨基酸,正常情况下经过分解代谢由肾脏排泄.目前普遍认为,当代谢途径受阻导致血浆中Hcy浓度大于10～15μmol/L时,会诱发一系列的血管性病理损害,并将血浆浓度大于此范围称为高同型半胱氨酸血症（hyperhomocysteinemia,HHcy）[1-2].目前大量研究已经证实,HHcy是导致脑卒中的独立危险因素,并可与高血压协同作用增加缺血性脑梗死的发病风险[3].
作者 卢健聪 谢海群 王玉凯 黄淑云 张国华 陈静娟 章成国
机构地区 广东省佛山市第一人民医院(中山大学附属佛山医院)神经内科
出处 《中华神经科杂志》 CAS CSCD 北大核心 2016年第6期495-498,共4页 Chinese Journal of Neurology
基金 基金项目：广东省自然科学基金资助项目（s2012010009715）
关键词 高同型半胱氨酸血症 血管病 脑卒中 血浆浓度 独立危险因素 缺血性脑梗死 HHCY 高半胱氨酸
分类号 R743.3 [医药卫生—神经病学与精神病学]
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参考文献36

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  • 2Saeco RL, Adams R, Albers G, et al. Guidelines for prevention of stroke in patients with ischemie stroke or transient ischemic attack: a statement for healtheare professionals from the American Heart Association/American Stroke Association Council on Stroke: co-sponsored by the Council on Cardiovascular Radiology and Intervention: the American Academy of Neurology affirms the value of this guideline[ J]. Circulation, 2006, 113 (10) : e409- 449.
  • 3Wang CY, Chen ZW, Zhang T, et al. Elevated plasma homocysteine level is associated with ischemic stroke in Chinese hypertensive patients [J].Eur J Intern Med, 2014, 25 (6) : 538- 544. DOI: 10. lO16/j, ejim. 2014. 04. 011.
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  • 6Feng C, Bai X, Xu Y, et al. Hyperhomocysteinemia associates with small vessel disease more closely than large vessel disease [J]. Int J Med Sei, 2013, 10(4):408-412. DOI: 10.7150/ ijms. 5272.
  • 7脑小血管病诊治专家共识组.脑小血管病的诊治专家共识[J].中华内科杂志,2013,52(10):893-896. 被引量：142
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二级参考文献16

  • 1傅建辉,黄家星.合并小血管病的颅内大动脉狭窄患者的预后[J].神经病学与神经康复学杂志,2010,7(1):12-16. 被引量：19
  • 2俞羚,董荃,宋叶平,江静雯,李卉,刘亮贤,苏爱萍,李焰生,Sacco RL,Kasner SE,Broderick JP,Caplan LR,Connors JJ,Culebras A,Elkind MS,George MG,Hamdan AD,Higashida RT,Hoh BL,Janis LS,Kase CS,Kleindorfer DO,Lee JM,Moseley ME,Peterson ED,Turan TN,Valderrama AL,Vinters HV.面向21世纪的卒中新定义:美国心脏病学会和美国卒中学会声明[J].神经病学与神经康复学杂志,2013,10(2):105-120. 被引量：198
  • 3各类脑血管疾病诊断要点[J].中华神经科杂志,1996,29(6):379-380. 被引量：33020
  • 4谈晓牧,刘建国,刘怀翔,高海风,张哲成.高同型半胱氨酸血症与脑梗死复发率关系的随访研究[J].中华神经科杂志,2006,39(9):591-594. 被引量：51
  • 5Dayal S, Arning E, Bottiglieri T, et al. Cerebral vascular dysfunction mediated by superoxide in hyerhomocysteinemic mice. Stroke, 2004, 35 : 1957-1962.
  • 6Ventura P, Panini R, Verlato C, et al. Peroxidation indices and total antioxidant capacity in plasma during hyperhomocysteinemia induced by methionine oral loading. Metabolism, 2000,49 : 225- 228.
  • 7Poddan R, Sivasubramanaian N, Dibello PM, et al. Homocysteine induces expression and secretion of monocyte chemoattractant protein-1 and interleukin-8 in human aortic endothelial cell: implications for vascular disease. Circulation, 2001, 103 : 2717- 2723.
  • 8Geisel J, Jodden V, Obeid R, et al. Stimulatory effect of homocysteine on interleukin-8 expression in human endothelial cells. Clin Chem Lab Med ,2003 ,41 : 1045-1048.
  • 9Wang G, Dai J, Mao J, et al. Folic acid reverses hyper-responsiveness of LPS-induced chemokine secretion from monocytes in patients with hyperhomocysteinemia. Therosclerosis, 2005,179:395-402.
  • 10Zeng X, Dai J, Remick DG, et al. Homocysteine mediated expression and secretion of monocyte chemoattractant protein-1 and interleukin-8 in human monocytes. Circ Res,2003,93 : 311-320.

共引文献157

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二级引证文献35

中华神经科杂志
2016年 第6期

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