天然药物对动脉粥样硬化中炎症的调控及机理研究进展

Recent Advances in Regulation of Natural Medicine on Inflammation in Atherosclerosis

动脉粥样硬化(atherosclerosis,AS)是动脉的慢性退化和动脉壁逐渐变化的过程,炎症贯穿于病变发生和发展的全过程。目前AS的研究主要集中于炎症细胞、炎性介质及免疫机制的相互作用方面。大量研究显示,天然药物对AS中炎症反应有明显的调节作用。本文对炎症的触发机制、AS初期、AS中炎症发展与并发症三个方面以及涉及的天然药物对AS治疗的相关研究进行总结,以期为今后天然药物对AS中炎症的调控及机理研究提供参考。

Atherosclerosis （AS） is a chronic process of gradual degradation and changes in arteries. Inflammation isinvolved in the entire development process of atherosclerosis. Currently , researches of AS focus on the interaction ofinflammatory cells , inflammatory mediators and immune mechanisms. A large number of studies have shown that naturalmedicine play a regulatory role on inflammation in AS. This revie＇w summarizes triggers for inflammation , initiation of the ASand inflammation in atheroma progression and complication , as well as researches involved medicine. This article may provide some theoretical basis for future researches on regulation and the mechanism of naturalmedicine treatment for inflammation in AS.