甲状旁腺激素在颅颌面骨再生研究中的应用进展

The progress in application of parathyroid hormone in craniomaxillofacial bone regeneration study

甲状旁腺激素（parathyroid hormone,PTH）是由甲状旁腺主细胞合成并分泌的多肽类激素,具有分解代谢和合成代谢的双重作用.在骨质疏松症、骨缺损、促骨折愈合中,主要通过调节成骨细胞、破骨细胞、骨骼内衬细胞等多种类细胞系的增殖和分化,同时激活多种信号途径,从而调节钙、磷代谢以及骨的转换以促进骨再生与重建.然而,PTH促进颅颌面骨再生的研究相对较少,其在颅颌面骨中的作用及相关作用机制与长骨是否一致还需要更多的实验证实.现就近几年PTH在颅颌面骨再生中的前沿研究作一综述,旨在为PTH在口腔颌面部的应用与研究提供参考.

Parathyroid hormone（PTH） is synthesized and secreted by chief cell of Gley＇s glands which possesses dual functions of catabolism and anabolism.It regulates the proliferation and differentiation of multiple cell lines including osteoblast,osteoclast and skeletal lining cells.Furthermore,PTH activates various signaling pathways which control calcium,phosphorous＇ metabolism and bone conversion,accelerating the bone regeneration and reconstruction.However,the study of PTH in craniomaxillofacial bone regeneration is relatively less and whether the role of parathyroid glands and the mechanism of ossification are consistent with the long bone or not needs further investigation.This review focuses on the progress of PTH in craniomaxillofacial bone regeneration in recent years.