摘要
葫芦素 B(CuB)是中药甜瓜蒂的主要成分,为四环三萜类物质。葫芦素 B 0.1mg/kg 即能提高小鼠外周血液 T 淋巴细胞数;0.2 mg/kg 能提高 PHA 诱导的 T 淋巴细胞转化率和脾脏空斑形成细胞数;0.4 mg/kg 时血清溶血素水平也明显增加。较大剂量(0.8mg/kg)时碳粒廓清率及腹腔巨噬细胞吞噬率显著提高。结果表明:葫芦素 B 能增强整个免疫系统功能,对细胞免疫的作用最强,对体液免疫也有较强作用。
Cucurbitacin B(CUB)is a major active principle contained in the calyx melo of Cucumis melo L.The immunopotentiating effects of CuB(im,qd×5)were studied.At lower doses, CuB increased the number of peripheral blood T lymphocytes(0.1 mg/kg),the rate of PHA-induced lymphocyte transformation(0.2 mg/kg),the number of plaque forming cells(PFC)of the spleen(0.2 mg/kg)and the level of serum hemolysin(0.4 mg/kg).The phagocytosis of macrophages and the clearance rate of charcoal particles were enhanced only by a large dose(0.8 mg/kg).The results indicate that CuB can potentiate both cellular and humoral immune function.
