低氧对种植术后骨重建细胞的影响

Effect of hypoxia on bone remodeling cells after dental implantation

牙种植术后常造成牙周低氧,加重了牙槽骨的骨吸收,导致骨量不足,是即刻种植或延期种植失败的主要原因之一。如何促进拔牙窝新骨形成和避免拔牙区牙槽骨的吸收萎缩,对于后期的种植修复具有重要的临床意义。未来的牙槽骨增量技术将会更多地涉及到分子、细胞、组织工程、基因治疗等领域。成骨细胞、破骨细胞和牙周膜成纤维细胞是骨重建过程中的重要细胞。本文主要从细胞水平综述低氧对种植术后骨重建的影响,为新的骨增量方法提供理论基础。

Periodontal hypoxia after dental implantation, which increases the resorption of alveolar bone and leads to the shortage of bone mass, is one of the main failure causes for immediate or delayed implantation. How to promote the osteogenesis and avoid the absorption and atrophy of alveolar bone in tooth extraction socket is of important clinical significance for the latter repair of implantation.The future techniques of alveolar bone augmentation will relate to the fields of molecule, cell, tissue engineering, gene therapy, et al.Osteoblasts, osteoclasts and periodontal ligament fibroblasts are the important cells in the process of bone remodeling. This review summarized the effect of hypoxia on the bone remodeling after dental implantation in cellular level and provided theoretical foundation for the new approaches of bone augmentation.