雄激素受体与雄激素在老年男性高血压中的变化及临床意义

Changes and Clinical Significance of Androgen Receptor and Androgen in Elderly Male Patients with Hypertension

目的:探讨老年男性高血压患者雄激素及其受体变化的临床意义。方法:选取老年男性高血压患者43例,另选取健康老年人43例。检测两组体质量指数(BMI)、血糖水平、体脂含量及雄性激素水平,检测的雄性激素包括游离睾酮(FT)、总睾酮(TT)、雌二醇(E2)、性激素结合球蛋白(SHBG)、硫酸脱氢表雄酮(DHEA-s),检测雄激素受体(AR)荧光强度。使用多因素Logistic回归分析高血压组雄性激素水平与雄性激素受体、体质量指数相关性。结果:高血压组的BMI、空腹血糖、高密度脂蛋白(HDL)、胆固醇(CH)、TT等指标与健康组比较,差异具有统计学意义(P<0.05);TT与BMI呈负相关(P=0.0023),TT与AR荧光强度呈正相关(P=0.0360)。结论:血浆雄激素水平对老年高血压发病危险因素进行评估,是评估危险因素新指标。

Objective To investigate the clinical significance in elderly male patients with hypertension of androgen and its receptor changes. Methods 43 cases in elderly male patients with essential hypertension（EH）, and 43 healthy elderly patients were selected. Two groups of body mass index（BMI）, blood glucose levels, and body fat content of the male hormone level, the male hormone including free testosterone（FT）, total testosterone（TT）, estradiol（E2）, sex hormone binding globulin（SHBG）, copper sulfate hydrogen table dehydroepiandrosterone（DHEA-S）,and androgen receptor（AR） were detected. Multivariate logistic regression analysis of hypertension group of male hormone Flat and androgen receptor（AR） and body mass index correlation. Results In hypertension group, BMI, fasting blood glucose, HDL ch, TT indicators and health groups had significant difference; TT and BMI was negatively correlated（P = 0.0023）, TT and androgen receptor（AR fluorescence intensity） was positively correlated P=0.0360. Conclusions Plasma androgen levels can be evaluated as elderly hypertension new risk factor.