食物不耐受及食物过敏与肠易激综合征的临床研究

Clinical study of food intolerance and food allergy with irritable bowel syndrome

目的:探讨食物特异性Ig G、Ig E与肠易激综合征(irritable bowel syndrome,IBS)的临床关联性。方法:对72例IBS患者和30例正常对照人群应用酶联免疫吸附法,检测其血清中亚洲人常见7种食物不耐受特异性Ig G抗体及8种常见食物过敏特异性Ig E抗体水平。结果:72例IBS患者中食物不耐受特异性Ig G至少1项阳性者48例,阳性率66.7%,显著高于对照组的44.3%(P<0.05)。IBS患者中特异性抗体水平等级中度及以上的占45.8%,两种以上食物特异性Ig G阳性的占56.9%。根据检查结果建议IBS患者剔除不耐受食物,8周后IBS症状改善30例(62.5%)。食物过敏特异性Ig E阳性率在IBS组(13.9%)和对照组(13.3%)差异无统计学意义。结论:食物不耐受在IBS的临床发病中起重要作用,可能是IBS的重要因素之一,食物过敏与IBS相关性不大。根据食物不耐受的检查结果建议患者剔除相应食物,可明显改善IBS临床症状。

Objective： To investigate the clinical relevance of food intolerance,food allergies and irritable bowel syndrome（ IBS）. Methods： The level of food intolerance specific Ig G antibodies and food allergy specific Ig E antibodies in serum from 72 patients with IBS and 30 healthy controls were detected by semi-quantitative enzymelinked immunosorbent assay. Results： In 72 patients with IBS,the food intolerance specific Ig G was positive in 48 cases,the positive rate was 66. 7 % which was significantly higher than the control group of 44. 3 %（ P〈0. 05）.And there were 45. 8 % of IBS patients in our study with moderate or severe levels of specific antibody. 56. 9 % of IBS patients in our study were found to have more than two kinds of high levels of food specific Ig G in serum.According to the results of the examination,the IBS patients were recommended to remove the intolerant food from the diet,and IBS symptoms were improved in 30 cases（ 62. 5 %） after 8 weeks. There was no significant difference between Ig E positive rates in IBS group（ 13. 9 %） and control group（ 13. 3 %）. Conclusion： Food intolerance plays an important role in the pathogenesis of IBS,and it may be one of the important factors of IBS.Food allergy is not associated with IBS within our experiment rang. According to the examination results of food intolerance,we give advices to patients to make the appropriate adjustments of diet, and the patients can significantly improve the clinical symptoms of IBS.