152例哈萨克族妇女卵巢早衰相关因素探讨

Study on the related factors of premature ovarian failure in 152 cases Kazakh women

目的：探讨引起哈萨克族妇女卵巢功能早衰（POF）的危险因素。方法：选取2014～2015年新疆伊犁州尼勒克县人民医院POF患者152例设为卵巢早衰组,选取同期进行体检的卵巢功能正常、月经周期规律的健康妇女80例为对照组。两组人员均进行全身各项身体检查,并填写女性生殖健康影响因素调查问卷。结果：两组在年龄、初潮年龄、体质量指数以及受教育程度方面差异无统计学意义（P〉0.05）;两组的促卵泡生成素、促黄体生成素以及雌二醇水平比较,差异有统计学意义（P〈0.05）。经Logistic单因素回归分析显示,婚姻状况、吸烟、饮酒、人工流产史、化学物质接触史、服用避孕药、家人关系、社会关系、家族史、糖皮质激素类药物为POF的危险因素,蔬菜、豆制品、体育锻炼为POF的保护因素,差异具有统计学意义（P〈0.05）。经Logistic多因素回归分析显示,吸烟、人工流产史、化学物质接触史、家族史为POF的危险因素,蔬菜、体育锻炼为POF的保护因素,差异具有统计学意义（P〈0.05）。结论：吸烟、人工流产史、化学物质接触史、家族史、蔬菜、体育锻炼与POF的发生有密切的相关性。因此,育龄期妇女要尽量做到不接触化学物质、不吸烟、避免人工流产、多食蔬菜和水果、多做运动,尽最大可能降低POF的发生率。

Objective： To explore the related factors of premature ovarian failure（ POF） in 152 cases Kazakh women. Methods： 152 cases of Kazakh women with POF from 2014 to 2015 in People＇s Hospital of Nilka County in Yili Prefecture of Xinjiang were selected as POF group. 80 healthy women with normal ovarian function and regular menstrual cycle were selected as the control group. The women in two groups were carried out all the physical examination,and filled in the female reproductive health influence factors questionnaire. Results： Terms of age,menarche age,body mass index and education degree between two groups had no significant differences（ P 0. 05）; Follicle stimulating hormone（ FSH）,luteinizing hormone（ LH） and estradiol（ E2） levels between two groups had significant differences（ P〈0. 05）. Logistic single factor regression analysis showed that marital status,smoking,drinking,history of artificial abortion,chemical substance contact history,taking birth control pills,family relationship,social relationship,family history,glucocorticoid hormone drugs were the risk factors of POF,vegetables,bean products and physical exercises were the protective factors of POF,and the differences were statistically significant（ P〈0. 05）. Logistic multiple regression analysis showed that smoking,history of artificial abortion,chemical substance contact history,family history were the risk factors of POF,vegetables,physical exercises were the protective factors of POF,the differences were statistically significant（ P〈0. 05）. Conclusion：Smoking,history of artificial abortion,history of chemical substances contact,family history,vegetables and physical exercises were closely related to POF. Therefore,women of childbearing age should try not to contact with chemicals and smoke,avoid artificial abortion,eat more vegetables and fruits,do more exercises,do the best possible to reduce the incidence of POF.