负性分子B7-H4在乳腺癌组织中的表达及其临床意义

Expression and clinical significance of B7-H4 in breast cancer

目的 :探讨负性分子B7-H4在乳腺癌组织中的表达情况及其与临床病理参数之间的关系。方法 :通过免疫组织化学技术分析68例乳腺癌组织和30例良性纤维瘤中B7-H4的表达情况,并结合临床资料统计分析B7-H4表达与乳腺癌患者临床特征之间的关系。结果:免疫组织化学结果显示,乳腺癌组织中B7-H4的阳性率为75%,明显高于纤维瘤组织(17%)(P<0.05),并与雌激素受体(estrogen receptor,ER)表达呈负相关、与人类表皮生长因子2(human epidermal growth factor receptor2,HER-2)呈正相关,而在年龄、肿瘤大小、病理类型等其他变量之间不存在显著差异。结论:乳腺癌组织中B7-H4异常表达,与乳腺组织良性病变存在差异(P<0.05),并与ER、HER-2的表达相关,提示B7-H4分子在乳腺癌的发生发展过程中起了重要作用。

Objective：To discuss the expression of B7-H4 protein in breast cancer tissues as well as the relationship among clinical pathological parameters. Methods：Immunohistochemical technique was employed to investigate the expression of B7-H4 in 68 cases of breast cancer and 30 cases of benign fibroadenoma. And statistical analysis was carried out to study the relationship between B7-H4 and pathological parameters. Results：The B7-H4 positive rate of breast cancer was 75%,significantly higher than fibroadenoma tissues（17%）（P 〈 0.05）. And highly expression of B7-H4 was negatively correlated to estrogen receptor（ER） but positively correlated to human epidermal growth factor 2 correlation（HER-2）, independent from other factors such as age,size of tumor and clinical stage.Conclusion：Aberrant B7-H4 expression in breast cancer but not benign fibroadenoma implied that B7-H4 may play an important role in the development of breast cancer.