摘要
The interaction of cisplatin and its analogues with phospholipid molecules of hu-man erythrocyte membranes was studied using IR and ￣31 P NMR methods. Dramatic changes were ob-served at 1300～953 cm￣-1 frequency region on the IR spectra .Based on the IR data analysis, it was speculated that the Pt(II) complexes interacted mainly with the polar head groups of phospholipids through electrostatic interaction and certain coordination patterns. The 1 2 h dynamic experiment showed that a recoverable process occurred in case of cis-DCDP and an unrecoverable one for other pt(II)analogues.A similar conclusion could be obtained from￣31 P NMR experimental results.The di-versity was discussed.
本文采用ＩＲ和￣３１ＰＮＭＲ方法研究了顺铂及其类似物与人红细胞膜磷脂的相互作用。与对照相比，顺铂及其类似物加入人红细胞膜以后，使得红外波谱的１３００～９５３ｃｍ￣－１频区发生明显改变。结果分析提示，顺铂等铂配合物通过静电相互作用和某些配位的方式，即主要与磷脂的极性头部相互作用。１２小时动力学实验进一步表明顺铂的作用是一个可恢复的作用过程，而其它的铂配合物的作用则不可恢复。￣３１ＰＮＭＲ实验得到与ＩＲ分析相似的结果。对此进行了讨论。
