中药复方诱导肿瘤细胞凋亡研究进展

The Research Progress of Mechanism on Inducing Apoptosis by Traditional Chinese Medicine in Tumor Cells

在当前肿瘤细胞凋亡研究大趋势下,近年来中医药深入分子生物学领域探究凋亡具体机制有众多实验研究。文章综述了近年来中药复方诱导恶性肿瘤细胞产生凋亡具体机制实验探究的理论成果。中药复方在多基因、多因素等多方面诱导肿瘤细胞发生凋亡,主要包括阻滞细胞分裂的周期,诱导凋亡和清除体内活性氧;增强或抑制基因的表达;激活凋亡过程中线粒体、内质网、死亡受体信号转导通路和caspase家族诱导的信号通路等,同时能抑制端粒酶的活性等。

In the current trend of apoptosis of tumor cell research, numerous experimental study have been made about review of studies on Molecular Biology of apoptosis induced by traditional chinese medicine in recent years. Many heoretical results of specific echanisms experimental exploration have been reports that apoptosis induced by traditional Chinese medicine in cancer cells in recent years was reviewed comprehensively in this article. Chinese herbal compound plays an important role in polygenic,multifactorial and multifaceted induce tumor cell apoptosis. The antitumor mechanism is associated with the arrest of cell cycle and the inhibition of telomerase activity, strengthen or suppress the expression level of apoptosis gene, activation of mitochondria signaling pathways, endoplasmic reticulum signaling pathways and death receptor signaling pathway and induction of caspase family of signaling pathways in apoptosis and elimination of harmful oxydases