益气活血运脾方对反复呼吸道感染患儿免疫功能的影响

Influence of immunologic function for treating pediatric patients with recurrent respiratory tract infections with Yihuoxueyunpi decoction

目的探讨自拟益气活血运脾方对反复呼吸道感染患儿免疫功能的影响。方法选择我院收治的136例反复患呼吸道感染患儿,随机分为对照组和治疗组,各68例。对照组给予匹多莫德颗粒,0.4 g/次,2次/d;治疗组则联合给予自拟益气活血运脾方内服,连续治疗1个月。对比2组临床疗效,评价中医证候积分及用药的安全性,统计治疗前后患儿的复发情况。结果治疗组临床疗效91.2%,明显优于对照组的75.0%(P<0.05);咳喘、食少纳呆、少气懒言、汗多等中医证候评分显著低于对照组,且症状的改善时间较对照组显著缩短(P<0.05);治疗组机体免疫力优于对照组,T细胞亚群CD3^+、CD4^+、CD4^+/CD8^+水平明显高于对照组,而CD8^+水平则显著低于对照组,其血清免疫球蛋白IgG、IgA、IgM水平显著高于对照组(P<0.05);治疗组随访1年内的患病次数明显少于对照组,患病病程短于对照组(P<0.05)。结论益气活血运脾方治疗反复呼吸道感染患儿疗效肯定,有利于加快临床症状的消退,减少复发,其机制与提高机体免疫功能有一定相关性。

Objective To investigate the clinical efficacy of treating pediatric patients with recurrent respiratory tract infections with yihuoxueyunpidecoction,and explore the influence of immunologic function. Methods 136 pediatric patients with recurrent respiratory tract infections were randomly divided into a control group of 68 cases and an observation group of 68 cases. Patients in the control group were treated with pidotimod granules,0. 4 g / time,2 times /d;,while patients in the observation group were treated with yihuoxueyunpidecoction,1month fortreatment. The research was aimed at comparing the effectiveness,evaluating the main respiratory syndromes points and the safety,recording the relapse pretherapy and post-treatment. Results The efficiency of patients in the observation group was91. 2%,which was better than that of the control group 75%（ P〈0. 05）; The improvement of main clinical symptoms for the patients in the observation group was better than that for the patients in the control group,the symptoms scores of cough,loss of appetite,indigestion,weak and sweat morewere lower than that of the control group,and the improvement time of the main symptoms was shorter than that of the control group（ P〈0. 05）; The improvement of immunologicfunction for the patients in the observation group was better than that for the patients in the control group,and the levels of CD3^＋,CD4^＋ and CD4^＋/ CD8^＋were higher than that of the control group,while the level of CD8^＋ was lower than that of the control group,the levels of Ig G,Ig A and Ig M were higher than that of the control group（ P〈0. 05）;The number of sick for the patients in the observation group follow-up of 1 year after treatment was less than that of the control group,and the disease progression was shorter than that of the control group（ P〈0. 05）. Conclusion Yihuoxueyunpidecoction has certain curative effect for treating pediatric patients with recurrent respiratory tract infections. It canspeed up the relief of symptoms and reduce recurrence,the mechanism may be associated with improving the body＇s immune function,is worthy of further research and development.