听神经瘤不同生物学行为的分子机制研究进展

Research advances in molecular mechanisms underlying the different biological behaviors of vestibular schwannoma

听神经瘤临床生物学行为的多变性，使其治疗策略不能仅限于传统手术治疗。近年来有关听神经瘤发病机制的分子生物学研究表明，听神经瘤的发展趋势与merlin蛋白的穿梭特性或表达状态密切相关，深入研究该蛋白的功能可能会发现潜在药物治疗靶点，从而控制肿瘤生长。

Current treatment options of vestibular schwannomas should not be limited to conventional surgery because of the variability of tumor growth. Recent studies of vestibular schwannomas suggested that the development of the tumor tended to depend on the shuttle between the nucleus and cytoplasm, and the expression patterns of merlin protein. New drug targets for schwannoma therapies might be identified through future in-depth investigations of the function of merlin, thus contributing to tumor control.