阿尔茨海默病患者平衡功能与认知功能的相关性

The Correlations of Balance Function and Cognition Function in Patients with Alzheimer's Disease

目的:了解与分析阿尔茨海默病(AD)患者平衡功能与认知功能的关系。方法:对80例AD患者,以Berg平衡量表(BBS)、蒙特利尔认知评估量表(MoCA)分别评定其平衡功能、认知功能;并按BBS评分,将AD患者区分为平衡功能障碍组、平衡功能受损组、平衡功能正常组后,进行比较性分析及相关性分析。结果:1平衡障碍组MoCA总分显著低于平衡受损组(d=1.51,P<0.001)、平衡正常组(d=3.47,P<0.001),平衡受损组又显著低于平衡正常组(d=1.98,P<0.01)。平衡障碍组MoCA注意/计算力得分显著低于平衡正常组(d=0.63,P<0.05);视空间/执行得分显著低于平衡受损组(d=0.54,P<0.05)、平衡正常组(d=1.00,P<0.001)。平衡受损组MoCA视空间/执行得分显著低于平衡正常组(d=0.51,P<0.05);2BBS总分与MoCA总分(r=0.435,P<0.001)、注意/计算力(r=0.226,P<0.05)、视空间/执行(r=0.355,P<0.01)正相关;BBS静态平衡分与MoCA总分(r=0.394,P<0.001)、注意/计算力(r=0.223,P<0.05)、视空间/执行(r=0.314,P<0.01)正相关;BBS动态平衡分与MoCA总分(r=0.427,P<0.001)、注意/计算力(r=0.255,P<0.05)、视空间/执行(r=0.357,P<0.01)、定向力评分(r=0.240,P<0.05)正相关。结论:AD患者的平衡功能障碍与认知功能,特别是注意/计算力、视空间/执行能力的受损有关。

Objective：To explore the relationships between balance function and cognition function in patients with Alzheimer＇s disease（AD） .Methods：Eighty AD patients were recruited and measured by Berg balance scale（BBS）and Montreal cognitive assessment（MoCA）to evaluate balance function and cognition function respectively ,and divided into three groups according to the scores of BBS including balance disfunctiongroup（n=19） ,impaired balance group （n=27） ,normal balance group（n= 34） .Results：AD patients with balance disfunction had lower scores of MoCA than those with impaired balance（d=1 5.1 ,P〈0 0.01）or normal balance patients（d=3 .47 ,P〈0 .001） ,while the former lower than the later（d=1 9.8 ,P〈0 0.1） .AD patients with balance disfunction also had lower scores of atten‐tion /calculation（d=0 6.3 ,P〈0 0.5）or visuospatial /executive function（d=1 .00 ,P〈0 0.01）compared with those normal balance AD patients ,and decreased subscale score of visuospatial/executive function（d=0 5.4 ,P〈0 0.5）com‐pared with those impaired balance AD patients .with impaired balance had lower subscale scores of visuospatial/exec‐utive function（d=0 5.1 ,P〈0 0.5）than those AD patients with normal balance .The scores of BBS was positively re‐lated with scores of MoCA（r=0 4.35 ,P〈0 0.1） ,subscale score of attention /calculation（r=0 2.26 ,P〈0 0.5） ,and visuospatial/executive function（r=0 3.55 ,P〈0 0.1） .The subscale score of static balance of BBS had a positive corre‐lation with scores of MoCA（r=0 3.94 ,P〈0 0.01） ,subscale score of attention /calculation（r=0 2.23 ,P〈0 0.5） ,and visuospatial/executive function（r=0 3.14 ,P〈0 0.1） .The subscale score of dynamic balance of BBS had positively correlated with scores of MoCA（r=0 4.27 ,P〈0 0.01） ,subscale score of attention /calculation（r=0 2.55 ,P〈0 0.5） , visuospatial/executive function（r=0 3.57 ,P〈0 0.1） or orientation（r=0 2.40 ,P〈 0 0.5） .Conclusion：The damaged balance function should associate with the impaired cognition ,especially attention /calculation and visuospatial /exec‐utive function in AD patients .