缺血性卒中患者阿司匹林抵抗的发生率及与合并糖尿病关系分析

Analysis on Incidence of Aspirin Resistance and its Correlation with Diabetes Mellitus in Patients with Ischemic Stroke

目的调查阿司匹林抵抗(aspirin resistance,AR)的发生率,分析缺血性卒中AR与合并糖尿病的关系。方法收集首次发生缺血性卒中患者共162例予以阿司匹林治疗,根据AR将患者分为AR组,阿司匹林半抵抗组(aspirin semi responder,ASR)、AR+ASR组、阿司匹林敏感组(aspirin sensitive,AS),统计AR的发生率以及分析与糖尿病关系。结果(1)AR、ASR及AR+ASR发生率分别为32.72%(53/162),9.88%(16/162)和42.59%(69/162)。(2)AR组、AR+ASR组中合并糖尿病患者所占的比例较高,与AS组相比,差异有显著性(P<0.05)。结论 (1)在辽西地区,缺血性卒中病人长期正规服用阿司匹林仍有相当一部分存在AR,AR及ASR的总发生率为42.59%;(2)AR及ASR的发生可能与合并糖尿病有关。

Objective To study the incidence of Aspirin Resistance （ AR） and its correlation with diabetes mellitus in the pa-tients with ischemic stroke. Methods A total of 162 patients who suffered ischemic stroke for the first time were all treated with aspi-rin and divided into AR group, ASR （ Aspirin Semi Resistance） group, AR＋ASR group and AS （ Aspirin Sensitive） group. The inci-dence of AR was tallied and its correlation with diabetes mellitus was analyzed. Results （ 1 ） The incidences of the first 3 groups were indicated as 32. 72% （ 53/162 ） , 9. 88 % （ 16/162 ） , and 42. 59 % （ 69/162 ） respectively. （ 2 ） Compared with the AS group, the patients with diabetes mellitus accounted for a higher proportion in the AR and AR＋ASR group, with significant difference （P〈0. 05）. Conclusions （1） There are still a large number of patients who suffered from ischemic stroke with conventional use of aspirin in western Liaoning Province. The total incidence of AR and ASR is 42. 59%. （2） The AR and ASR may be related to diabe-tes mellitus.