血清胱抑素C对高血压、糖尿病患者早期肾损伤的诊断价值

The Diagnostic Value of Serum Cystatin C in Early Renal Damage for Patients with Hypertension and Diabetes

目的探讨血清胱抑素C(CysC)对高血压患者和糖尿病患者早期肾损伤的诊断价值。方法采用微粒子增强比浊法,用AEROSET全自动生化分析仪分别检测120例高血压患者(高血压组)、120例糖尿病患者(糖尿病组)和120例排除高血压、糖尿病、肾损伤的健康体检者(对照组)的血清CysC水平,计算3组血清CysC的检测阳性率和平均水平,分别用χ2检验和t检验的统计学方法比较组间的差异,分析血清CysC水平对高血压患者和糖尿病患者早期肾损伤的诊断价值。结果高血压组、糖尿病组和对照组的血清CysC检测阳性率分别为42.50%、22.50%和0%,高血压组和糖尿病组的血清CysC检测阳性率均显著高于对照组(P<0.01),并且高血压组的血清CysC检测阳性率显著高于糖尿病组(P<0.01),差异具有统计学意义;高血压组、糖尿病组和对照组的血清CysC平均水平分别为(1.19±0.57)、(0.99±0.51)和(0.81±0.17)mg/L,高血压组和糖尿病组的血清CysC水平均显著高于对照组(P<0.01),并且高血压组的血清CysC水平显著高于糖尿病组(P<0.01),差异具有统计学意义。结论高血压患者和糖尿病患者均容易导致肾损伤,但高血压患者较糖尿病患者更容易导致肾损伤;血清CysC水平检测对高血压患者和糖尿病患者的早期肾损伤具有一定的临床诊断价值。

Objective To explore the diagnostic value of serum cystatin C （ CysC） in early renal damage for patients with hyper-tension and diabetes. Methods Serum CysC of 120 hyperpietic patients （ hypertension group ） , 120 diabetic patients （ diabetes group） and 120 healthy subjects without hypertension, diabetes and renal damage （ control group） were tested respectively using AEROSET fully automatic biochemical analyzer by the micro particle enhanced turbidimetric method. The positive rates and average values of serum CysC in these three groups were calculated. The differences between the three groups were compared with 2 test and t test statistical methods respectively to analyze the diagnostic value of serum CysC in early renal damage for patients with hypertension and diabetes. Results The positive rate of serum CysC was 42. 50% in hypertension group and it was 22. 50% in diabetes group and 0 in control group. The positive rates of serum CysC in hypertension group and diabetes group were significantly higher than that in con-trol group （P〈0. 01）. The positive rate of serum CysC in hypertension group was significantly higher than that in diabetes group （P〈0. 01）. The differences in these three groups were statistically significant. The average value of serum CysC was （1. 19±0. 57） mg/L in hypertension group, （0. 99±0. 51） mg/L in diabetes group and （0. 81±0. 17） mg/L in control group. The average values of serum CysC in hypertension group and diabetes group were significantly higher than that in control group （P〈0. 01）. The average value of se-rum CysC in hypertension group was significantly higher than that in diabetes group （ P〈0. 01 ） . The differences in three groups were statistically significant. Conclusion Patients with hypertension and diabetes were likely to suffer kidney damage. Moreover, patients with hypertension were more likely to suffer kidney damage than those with diabetes. The test of serum CysC was of clinical value in di-agnosing the early renal damage for patients with hypertension and diabetes.