慢性肺心病治疗前后的血清hs-CRP及心肌酶水平等变化分析

Analysis of Changes of Serum Hs-CRP and Myocardial Enzyme Before and After Treatment of Chronic Cardiopulmonary Disease

目的探讨慢性肺心病急性发作期及治疗缓解期的血清超敏C反应蛋白、心肌酶及血清B型钠尿肽的变化。方法选取120例慢性肺心病患者,其中急性发作期60例,缓解期60例,检测其血清hs-CRP及心肌酶,并以60例健康体检者作为对照。结果慢性肺心病患者的hs-CRP、BNP、CK-MB、CK、LDH、AST水平显著高于健康对照组,而急性发作期则明显高于缓解期P<0.01。经治疗,急性发作期患者的hs-CRP、BNP及心肌酶水平均明显下降P<0.01。结论慢性肺心病患者血清hs-CRP、心肌酶水平显著升高,尤其是急性发作期,故可作为预测慢性肺心病产生、进展及疗效判断的重要指标。

Objective To investigate the changes of serum high-sensitivity C-reactive protein, myocardial enzyme and B-type natriuretic peptide of patients in the acute attack stage and remission stage of chronic cardiopulmonary disease. Methods 120 patients with chronic cardiopulmonary disease were selected, including 60 cases in the acute attack stage and 60 cases in the remission stage, and serum hs-CRP and myocardial enzymes of those patients were detected. 60 cases of healthy cases were selected into the control group. Results Hs-CRP, BNP, CK-MB, CK, LDH, AST levels of patients with chronic cardiopulmonary disease were signifi-cantly higher than those of the healthy patients in the control group, the levels of those indexes in the acute attack stage remarkably higher than those in the remission period （P〈0. 01）. After treatment, hs-CRP, BNP and myocardial enzyme levels of patients in the acute attack stage decreased significantly （P〈0. 01）. Conclusion Serum hs-CRP and myocardial enzyme levels obviously increases in the patients with chronic cardiopulmonary disease, especially in the acute attack stage, thus it can be regarded as an important indi-cator in the emergency, development and curative effect judgment of this disease.