慢性乙醇中毒性周围神经病患者执行功能的对照研究

The Controlled Study of Executive Function in Patients with Chronic Alcoholic Peripheral Neuropathy

目的:研究慢性乙醇中毒性周围神经病(CAPN)患者的执行功能。方法:以CAPN患者为研究组,同期健康志愿者为对照组,应用威斯康星卡片分类测验(WCST)、连线测验、Stroop数字计数测验、ODDBELL听觉任务、STERBERG视觉任务、双重视听追踪任务研究被试的执行功能。结果:1连线测验:研究组在"基础任务耗时"(t=2.233,P<0.05)、"附加任务耗时"(t=2.818,P<0.01)均显著高于对照组,在"基础任务正确率"(t=3.511,P<0.01)、"附加任务正确率"(t=2.578,P<0.05)均显著低于对照组;2Stroop数字计数测验:研究组在"基线测验耗时"(t=10.755,P<0.01)、"一致性测验耗时"(t=4.578,P<0.01)、"非一致性测验耗时"(t=4.354,P<0.01)均显著高于对照组,在"基线测验正确率"(t=3.706,P<0.01)、"一致性测验正确率"(t=2.287,P<0.05)、"一致性测验正确率"(t=4.661,P<0.01)均显著低于对照组;3WCST测验:研究组在TN(t=3.834,P<0.01)、CFC(t=4.145,P<0.01)、EN(t=5.777,P<0.01)、PE(t=15.112,P<0.01)、CN(t=7.267,P<0.01)均显著高于对照组,在CA(t=6.055,P<0.01)、FMSS(t=6.294,P<0.01)均显著低于对照组;4视听任务:研究组在"ODDBALL反应时间"(t=16.588,P<0.01)、"STERBERG反应时间"(t=16.892,P<0.01)、"双重任务追踪误差"(t=9.02,P<0.01)、"双重任务反应时间"(t=16.845,P<0.01)均显著高于对照组,在"ODDBALL反应正确率"(t=8.499,P<0.01)、"STERGERG反应正确率"(t=23.782,P<0.01)、"双重任务反应正确率"(t=13.749,P<0.01)均显著低于对照组。结论:CAPN患者在中枢神经系统临床表现出现前,已经存在脑部高级智能活动障碍,认知心理学检查有助于其早期诊断。

Objective ：To research the executive function of patients with chronic alcoholism peripheral neuropathy （CAPN） .Methods ：164 patients were involved in the study group （Group A） ,who were admitted primally as CAPN in No .153 Central Hospital of PLA and General Hospital of PLA from Jan .2009 to Jun .2014 .And 152 healthy volun‐teers were involved in the control group（Group B） .Wisconsin Card Sorting Test（WCST ） ,Wire Test ,Stroop Digital Counter Test ,ODDBELL Auditory Task ,STERBERG Visual Task and Dual Audio - Visual Tracking Task were used in both groups .Results ：The operation time of the study group were significantly higher than which of the con‐trol group in all tasks（t = 2 .233 - 16 .588 ,P 〈 0 .05） .The correct rates of the study group were significantly lower than those in the control group in all tasks（t = 2 .287 - 23 .782 ,P 〈 0 .01） .Conclusion ：In patients with central nervous system clinical manifestations of CAPN ,there have been a high level of brain activity disorder .The cognitive psychol‐ogy test will help them in early diagnosis .