当归四逆汤对糖尿病周围神经病变AEGs及其受体的影响

Effect of Danggui Sini decoction on AEGs of diabetic peripheral neuropathy and its receptor

目的:观察当归四逆汤对糖尿病周围神经病变的临床疗效及对患者AEGs和其受体的影响。方法:选取60例糖尿病周围神经病变患者随机分为治疗组和对照组,在糖尿病基础治疗基础上治疗组给予当归四逆汤,对照组给予甲钴胺片,比较两组患者临床疗效、治疗前后神经传导速度、血液流变指标及AEGs及其受体水平。结果:治疗后治疗组患者的运动神经(腓总神经)、感觉神经(胫神经、腓总神经)传导速度较对照组患者显著提高;全血黏度、血浆黏度及红细胞压积较对照组患者显著降低;AEGs及其受体水平较对照组患者显著降低,差异均具有统计学意义(P<0.05)。结论:在糖尿病基础治疗之上加服当归四逆汤较加服甲钴胺片治疗糖尿病周围神经病变可提高临床疗效,加快神经传导速度,改善血液流变,最重要的是降低患者AEGs及其受体的水平参数。

Objective： To explore the clinical effects of Danggui Sini decoction on diabetic peripheral neuropathy,AEGs of patients and its receptor. Methods： 60 patients with diabetic peripheral neuropathy were randomly divided into treatment group and control group. On the basis of treatment of diabetes,the treatment group was treated with Danggui Sini decoction,while the control group was treated with Mecobalamin Tablets. The clinical effects,nerve conduction velocity before and after treatment,hemorheological parameters,AEGs and its receptor level were compared in patients of two groups. Results： After treatment,the conduction velocities of motor nerve（ common peroneal nerve） and sensory nerve（ tibial nerve,common peroneal nerve） of patients in treatment group were more significantly enhanced than that of patients in control group; whole blood viscosity,plasma viscosity and hematocrit were more significantly reduced than that of patients in control group; AEGs and its receptor level were also more significantly reduced than that of patients in control group. The differences were statistically significant（ P〈0. 05）. Conclusions： On the basis of treatment of diabetes,Danggui Sini decoction combined with Mecobalamin Tablets for diabetic peripheral neuropathy can enhance the clinical effects,speed up the nerve conduction velocity,and improve the blood rheology. It is most important to reduce the parameters of AEGs and its receptor level of patients.