基于功能磁共振成像分析不同眼睛状态下低频振幅比

Analysis of fractional amplitude of low-frequency fluctuation in different eyes statuses based on functional MRI

利用功能磁共振成像(f MRI)研究静息态睁眼、闭眼与眼睛生理性开合下人类功能连通性的改变。采用3.0 T西门子磁共振仪对16例志愿者进行扫描,获取不同眼睛状态下f MRI数据,利用低频振幅比提取数据特征,使用方差分析与双样本t检验分析静息态脑功能的差异。结果发现右侧中央后回、右侧颞上回、右侧舌回、左侧中央后回、左侧矩状裂及其周围皮层等脑区存在显著差异,3种状态之间的相互比较也检测出差异显著的脑区。研究表明睁眼、闭眼、自由状态对大脑f MRI的低频振幅比即特定脑区有一定的影响,会造成颞叶、枕叶等区域的差异,而这些差异均与视觉与认知活动相关。

Functional MRI （fMRI） was used in the study to investigate the human functional connectivity in the conditions of resting-state eyes open, eyes close and eyes free. Sixteen cases were scanned by 3.0 T Siemens MRI machine to obtain the fMRI data of different eyes statuses. The data features were extracted by fractional amplitude of low-frequency fluctuation （fALFF）. The results of variance analysis and two sample t test for resting-state brain function showed significant differences were found in the right postcentral gyms, right superior temporal gyrus, right lingual gyrus, left postcentral gyms, left fissura calcarina and surrounding cortex. And the brain regions with significant differences were also detected by the comparison among the three eyes statuses. The different eyes statuses, eyes open, eyes close and eyes free have affects on fALFF of brain fMRI, some specific brain regions, causing the differences of temporal lobe and occipital lobe which are relevant to visual and cognitive activities.