摘要
Incubation of camazepam [3-(N,N-dimethyl) carbamoyloxy-7-chloro-1- methyl-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one] with rat liver microsomes and cofactors produced a 3-(N-methyl-N-hydroxymethyl) carbamoyloxy derivative as the most abundant metabolite.This metabolite was thermally unstable and was isolated from a metabolite mixture by normal-phase High-Performance Liquid Chromatography.Its struc- ture was established by chemical ionization and ^(252)Cf plasma desorption time-of-flight mass spectral analyses.
卡马西泮[3-(N,N-二甲基)氨甲酯-7氯-1-甲基-1,3-二氢-5苯基-2氢-1,4-苯并二氮草-2酮)经以鼠肝微粒体作体外代谢,其主要代谢产物为3-(N-甲基-N-甲氧基)氨甲酯衍生物。此类代谢产物对热不稳定,难以普通质谱技术测定。本文报道了用^(252)Cf 等离子体解吸质谱法的分析结果。
