中药灌肠治疗溃疡性结肠炎的临床研究

Clinical Study on Chinese Medicine Enema for Treating Ulcerative Colitis

为探讨中药青黛、黄芪、党参、金银花、黄连、乳香、没药、延胡索、五倍子灌肠治疗溃疡性结肠炎的疗效，将经结肠镜检查并经病理检查诊断为溃疡性结肠炎的患者随机分为治疗组和对照组各70例。治疗组用以上中药各6g水煎至200mL保留灌肠，每晚1次，疗程14d。对照组用庆大霉素16万U，利多卡因50mg，地塞米松5mg加生理盐水200ml，保留灌肠，每晚1次，疗程14d。结果显示，治疗组完全缓解42例，占60．0％，有效23例，占32．9％，无效5例，占7．1％，总有效率92．9％。对照组完全缓解28例，占40．0％，有效25例，占35．7％，无效17例，占24．3％，总有效率75．7％。2组有显著性差异（P〈0．01）。2组随访半年，治疗组随访55例，复发5例，复发率9．1％；对照组随访50例，复发12例，复发率24．0％。结果表明，中药灌肠治疗溃疡性结肠炎药源广泛，方法简单，疗效确切，价格便宜，副作用少，复发率低。

This study was to investigate the effect of Chinese medicine enema for treating ulcerative colitis （UC） ,randomly divided 140 cases of UC who had been confirmed UC through coloscopy and pathological exam. into treatment group and control one, 70 cases for each; the former gave retention enema（1 time/ night,lasted 14 days） with Chinese drugs as Indigo naturalis , Radix Astragali , Radix codonopsis Pilosulae , Flos Lonicerae,Rhizoma Coptidis , Resina Olibani , Commiphora Myrrha , Rhizoma Corydalis and Galla Chinensis which each weight was 6 g,together added water and boiled up to 200 mL, while to the latter Gentamycin 16 ×10^4 U, Lidocaine 50 mg,Dexamethasone 5 mg, physiological saline 200 mL for retention enema, 1 time/night,for 14 days.As results,in the former 42 cases（60.0%） got CR（complete remission）, 23 were （32.9 %） of response, 5 （7.1%） of non-response, thus total effective rate was 92.9% ;while in the latter 28 cases（40.0%）,25 （35.7%）, 17 （24.3%）, thus 75.7%, there was significant difference（ P 〈0.05） ;the follow-up of half yr. for 55 cases of the former found that 5 cases were of recurrence,its rate was 9.1% ;for 50 cases of the latter 12 cases were of recurrence,its rate was 24.0%.Results show that Chinese medicine enema for UC has such merits as drug-resource extending, method simple, effect determined, economic cost, less side efficacy and low recurrence rate.