郑州市狂犬疫苗接种人群免疫效果分析

Analysis of immune effects in rabies vaccination people in Zhengzhou

目的了解河南省郑州市狂犬病暴露后人群接种狂犬疫苗的群体免疫效果。方法收集狂犬病暴露人群免疫前和免疫后血清标本,以快速荧光灶抑制试验（RFFIT）检测抗狂犬病病毒中和抗体（RVNAs）,采用SPSS 17.0软件进行统计学分析。结果 RFFIT检测结果及统计学分析显示,2份免疫前血清RVNAs〉0.5 IU/ml,免疫后血清RVNAs呈阳性;狂犬疫苗免疫前后RVNAs差异有统计学意义（Z=-7.009,P=0.000）,免疫后血清阳转率在性别和年龄方面差异无统计学意义（Z=-1.287,P=0.18和χ^2=2.606,P=0.626）;免疫后RVNAs与接种者性别差异有统计学意义（Z=-2.229,P=0.026）,与接种者年龄差异无统计学意义（χ^2=6.197,P=0.185）;RVNAs水平与免疫后年限差异有统计学意义（χ^2=18.654,P=0.000）。结论河南省郑州市狂犬病暴露后人群狂犬疫苗总体免疫效果良好,免疫前RVNAs〉0.5 IU/ml的个体应引起关注。

Objective To investigate the population immune effect of rabies vaccination in population exposed to rabies in Zhengzhou of Henan. Methods To collect the serums before and after the full course rabies vaccine. RFFIT was used to test the rabies neutralizing antibodies（ RVNAs）,SPSS 17. 0 was used for statistical analysis. Results RFFIT testing results and statistical analysis showed that 2 copies of the immune serum RVNAs 0. 5 IU / ml,the immuned serum RVNAs was positive;before and after rabies vaccine,the RVNAs differences had statistical significance（ Z =-7. 009,P = 0. 000）. There were no statistical significance on the difference of positive transfer rates between ages and genders（ Z =-1. 287,P = 0. 18,χ2=2. 606,P = 0. 626）. There was statistical significance on the difference between RVNAs and genders rabies vaccinated people after immune（ Z =-2. 229,P = 0. 026）,but there was no statistical significance on the difference with ages（ χ2= 6. 197,P =0. 185）. There was statistical significance on the difference between the RVNAs levels and the years after immune（ χ2=18. 654,P = 0. 000）. Conclusion The rabies vaccine immune effect of the rabies exposure people is generally good in Zhengzhou of Henan. Persons who have the RVNAs ≥ 0. 05 IU / ml before immune need to be focused on.