促炎因子与脑梗死患者肺部感染的相关性临床分析

Clinical analysis of relationship between proinflammatory cytokines and pulmonary infections in cerebral infarction patients

目的分析及研究促炎因子与脑梗死患者肺部感染的相关性,为脑梗死患者肺部感染的预防和控制提供依据。方法选取2013年4月-2015年6月于医院进行治疗的46例脑梗死肺部感染患者为A组,同期的46例脑梗死未发生肺部感染患者为B组,46名健康人员为C组,将3组研究对象的血清促炎因子水平进行比较,并比较A组中轻度、中度及重度肺部感染患者的血清促炎因子水平,并以logistic分析促炎因子与脑梗死肺部感染的相关性。结果 A组的血清促炎因子包括白细胞介素-1β(IL-1β)、白细胞介素-4(IL-4)、白细胞介素-6(IL-6)及肿瘤坏死因子-α(TNF-α)水平,分别为(3.15±0.29)pg/ml、(78.59±9.96)ng/L、(12.53±1.56)pg/ml及(2.84±0.25)ng/ml,其均明显高于B组及C组水平,且B组高于C组水平;A组中重度肺部感染患者的血清IL-1β、IL-4、IL-6及TNF-α水平分别为(4.86±0.34)pg/ml、(87.69±12.15)ng/L、(15.63±1.78)pg/ml及(3.69±0.32)ng/ml,其均高于轻度及中度肺部感染水平,中度肺部感染则高于轻度肺部感染水平;经logistic分析显示,上述血清指标均与脑梗死肺部感染有密切关系,差异均有统计学意义(P<0.05)。结论脑梗死肺部感染患者的促炎因子呈现高表达状态,且与脑梗死有密切的相关性。

OBJECTIVE To study the relationship between proinflammatory cytokines and pulmonary infections in cerebral infarction patients so as to provide guidance for prevention and control of pulmonary infections in the cerebral infarction patients.METHODS Totally 46 cerebral infarction patients with pulmonary infections who were treated in the hospital from Apr 2013 to Jun 2015 were assigned as the group A,meanwhile,46 cerebral infarction patients without pulmonary infections were chosen as the group B,and 46 healthy people were set as the group C.The levels of serum proinflammatory cytokines were compared among the three groups of study objects,the levels of serum proinflammatory cytokines were compared among the patients with mild,moderate,and severe infections in the group A.The logistic analysis was conducted to observe the relationship between the proinflammatory cytokines and the pulmonary infections in the cerebral infarction patients.RESULTS The levels of interleukin-1β（IL-1β）,interleukin-4（IL-4）,interleukin-6（IL-6）,and tumor necrosis factor-α（TNF-α）of the group A were respectively（3.15±0.29）pg/ml,（78.59±9.96）ng/L,（12.53±1.56）pg/ml,and（2.84±0.25）ng/ml,significantly higher than those of the group B fand the group C;the levels of the above serum proinflammatory cytokines of the group B were higher than those of the group C.In the group A,the levels of serum IL-1β,IL-4,IL-6,and TNF-αof the patients with severe pulmonary infections were respectively（4.86±0.34）pg/ml,（87.69±12.15）ng/L,（15.63±1.78）pg/ml,and（3.69±0.32）ng/ml,higher than those of the patients with mild pulmonary infections and the patients with moderate pulmonary infections;the levels of the above serum proinflammatory cytokines of the patients with moderate pulmonary infections were higher than those of the patients with mild pulmonary infections.The logistic analysis indicated that the above serum indicators were closely associated with the pulmonary infections in the cerebral infarction patients,and there was significant difference（P〈0.05）.CONCLUSION The proinflammatory cytokines in the cerebral infarction patients with pulmonary infections show high expression status,which is closely associated with the cerebral infarction.