肺炎支原体感染与小儿咳嗽变异性哮喘的关系及大环内酯类药物治疗的效果分析

Relationship between Mycoplasma pneumoniae infection and cough variant asthma in children and effects of macrolides

目的探讨小儿咳嗽变异性哮喘与肺炎支原体感染的关系,以及大环内酯类药物治疗的临床疗效。方法选择2014年1月-2015年12月40例小儿咳嗽变异性哮喘患儿为观察组,40例肺炎支原体感染患儿为对照组,对两组患儿进行常规的血清检测,观察两组患儿的MP-IgM值,采用大环内酯类药物对两组患儿进行治疗。结果血清MP-IgM阴性率观察组患儿为47.5%,对照组患儿为60.0%,两组患儿的血清MP-IgM阴性率差异有统计学意义(P<0.05);血清总MP-IgM阳性IgM含量观察组患儿为(198.34±56.78)U/ml,对照组患儿为(195.16±58.29)U/ml,差异有统计学意义(P<0.05);大环内酯类药物进行治疗,观察组患儿治疗总有效率为92.5%;对照组为90.0%,两组患儿治疗有效率比较差异无统计学意义。结论小儿咳嗽变异性哮喘与肺炎支原体感染存在一定的关联,使用大环内酯类药物对肺炎支原体感染小儿咳嗽变异性哮喘治疗,有效率在90.0%以上。

OBJECTIVE To explore the relationship between cough variant asthma in children and Mycoplasma pneumoniaeinfection and observe the clinical effects of macrolides.METHODS Totally 40 children with cough variant asthma who were treated in the hospital from Jan 2014 to Dec 2015 were assigned as the observation group,and 40 children with M.pneumoniaeinfection were set as the control group.The conventional serological test was conducted for the two groups of children,the MP-IgM value of the two groups of children was observed,and the macrolides antibiotics were used for the treatment of the two groups of children.RESULTS The negative rate of serum MP-IgM was 47.5%in the observation group,60.0%in the control group,and there was significant difference in the negative rate of serum MP-IgM between the two groups of children（P〈0.05）.The serum total MPIgM positive IgM content was（198.34±56.78）U/ml in the observation group,（195.16±58.29）U/ml in the control group,and there was significant difference（P〈0.05）.After the treatment with macrolides,the total effective rate of treatment was 92.5%in the observation group,90.0%in the control group;there was no significant difference in the effective rate of treatment between the two groups of children.CONCLUSIONThere is certain correlation between the cough variant asthma in children and M.pneumoniaeinfection.The effective rate of macrolides is more than 90.0%in treatment of M.pneumoniaeinfection and cough variant asthma in children.