乳腺癌患者血清中血管内皮细胞生长因子和碱性成纤维细胞生长因子的表达情况被引量：8

导出

摘要目的对乳腺癌患者血清中血管内皮细胞生长因子(vascular endothelial growth factor,VEGF)和碱性成纤维细胞生长因子(fibroblast growth factor,FGF)进行检测,探讨血清中VEGF和FGF在乳腺癌中的意义。方法选择2004年6月-2014年5月台州市立医院肿瘤外科收治的85例乳腺癌患者为观察组,健康女性85例为对照组,比较两组血清中VEGF和FGF的表达情况以及乳腺癌类型、分期、大小和淋巴结转移和血清中VEGF和FGF表达的关系。结果观察组患者的血清中VEGF和FGF水平均明显高于对照组(P<0.05)。浸润性导管癌、导管内癌和浸润性小叶癌之间血清中VEGF和FGF表达比较差异无统计学意义(P>0.05)。乳腺癌Ⅰ期、Ⅱ期、Ⅲ期和Ⅳ期之间血清中VEGF和FGF表达比较,差异有统计学意义(P<0.05),乳腺癌直径≥2cm患者血清中VEGF和FGF水平均高于直径<2cm患者(P<0.05),有淋巴结转移患者VEGF和FGF水平均高于无转移患者(P<0.05)。结论乳腺癌患者血清中VEGF和FGF水平增加,血清中VEGF和FGF水平和乳腺癌的临床分期、肿瘤大小及有无淋巴结转移有关。

作者陈鑫

机构地区台州市立医院肿瘤外科

出处《中国妇幼保健》 CAS 2016年第12期2460-2462,共3页 Maternal and Child Health Care of China

关键词乳腺癌血管内皮细胞生长因子碱性成纤维细胞生长因子

分类号 R737.9 [医药卫生—肿瘤]

引文网络
相关文献

参考文献11

1Wallis L. Yet another breast cancer screening update [ J ]. Am J Nurs, 2016, 116 (4): 14-15.
2Cantirio AC, Cabral PU, Paiva LC, et al. Physical activity, fatigue and quality of life in breast cancer patients [ J ]. Rev Assoc Med Bras, 2016, 62 (1): 38-44.
3Moraes DC, Almeida AM, Figueiredo EN, et al. Opportunistic screening actions for breast cancer performed by nurses working in primary health care [ J]. Rev Esc Enferm USP, 2016, 50 (1) : 14-21.
4Kim E, Hou J, Han JY, et al. Predicting retweeting behavior on breast cancer social networks: network and content characteristics [J]. J Health Commun, 2016, 21 (4) : 479-486.
5Tan J, Joblin L, Davenport E. Accuracy of frozen sections for breast cancer sentinel lymph node biopsies within a peripheral New Zealand hospital [J]. N Z Med J, 2016, 129 (1431) : 46-50.
6Chiavarioa B, Martinez-Outschoorn UE, et al. Metabolic reprogram- ruing and two-compartment tumor metabolism: opposing role (s) of HIF1α and HIF2α in tumor-associated fibroblasts and human breast cancer cells [J]. Cell Cycle, 2012, 11 (17) : 3280-3289.
7Angelucci C, Maulucci G, Colabianchi A, et al. Stearoyl-CoA desat- urase 1 and paracrinc diffusible signals have a major role in the pro-motion ofbreasl cancer eell migration induced by cancer-associated fi- broblasts [J]. BrJCancer, 2015, 112 (10): 1675-1686.
8Wang S, Xu J, Zhang Q. Clinical signifieanee of survivin and vascular endolhellal growlh factor rnRNA detection in the peripheral whole blood of breast ealwer palicnts [ J]. Neoplasma, 2016, 63 (1) : 133-140.
9Sa-Nguanraksa D, Chuangsuwanich T, Pongpmttipan T, et al. High vascular endothelial growth factor gene expression predicts poor out- come in patients with non-lulninal a breast cancer [J]. Mol Chin Orwol, 2015, 3 (5): 1103-1108.
10Chen Z, Xu S, Xu W. et al. Expression of cluster of differentiation 34 and vascular endothelial growth factor in breast cancer, and their prognostic significance [ J ]. Oncol Lett, 2015, 10 (2): 723 -729.