低频经颅磁刺激联合认知疗法对儿童抑郁障碍的研究被引量：4

Study on the effect of repetitive low-frequency transcranial magnetic stimulation combined with cognitive therapy for children with depression

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摘要目的观察低频经颅磁刺激(rTMS)加认知疗法(CBT)治疗儿童抑郁障碍的疗效。方法将60例儿童抑郁障碍患者分成研究组即rTMS+CBT和对照组即假性刺激+CBT。以上2组均不采用药物治疗。观察2个月,采用儿童抑郁量表(CDI)的变化及差异,观察治疗前及治疗后第2周、第4周、第8周末抑郁情况的变化。结果治疗前即基线时研究组CDI分值(27.03±7.46)分,对照组(27.25±6.93)分,2组CDI分值比较差异无统计学意义(F=0.171,P=0.681)。时间点主效应表明,研究组患者治疗2周时CDI评分[(19.93±5.97)分]较基线降低,与对照组[(25.32±6.53)分]比较差异有统计学意义(F=12.585,P=0.001);治疗4周时研究组CDI评分[(12.17±3.75)分]较基线降低,且低于对照组[(23.39±6.3)分],差异有统计学意义(F=67.027,P=0.000)。经治疗8周后CDI评分[(11.9±3.31)分]明显下降,且显著低于对照组[(17.36±4.57)分],差异有统计学意义(F=30.874,P=0.000)。结论 rTMS联合CBT可有效治疗儿童抑郁障碍,值得临床推广。 Objective To observe the clinical effect of repetitive low-frequency transcranial magnetic stimulation （rTMS） combined with cognitive therapy （CBT） in treatment of children with depression. Methods Sixty children with depression were divided into experi- mental group and control group. The children in experimental group were treated with rTMS＋CBT, while the children in control group were treated with pseudo stimulation＋CBT; the children in the two groups were not treated by drug therapy. After two months, the childreri were e- valuated by Children＇s Depression Inventory （CDI） before treatment and on the second, the fourth, the eighth weeks after treatment. Results The baseline values of CDI in experimental group and control group before treatment were （27.03±7.46） and （27.25±6. 93 ）, re- spectively; there was no significant difference between the two groups （F= 0. 171 , P〉0. 05） . On the second week after treatment, CDI score in experimental group （19. 93±5.97） was significantly lower than the baseline, compared with control group （25.32±6. 53 ） , there was statistically significant difference （ F = 12. 585, P = 0. 001 ） ; on the fourth week after treatment. CDI score in experimental group （12. 17±3.75） was significantly lower than the baseline, compared with control group （23.39±6. 3）, there was statistically significant difference （ F=67. 027, P=0. 000） ; on the eighth week after treatment, CDI score in experimental group （ 11.9±3.31 ） decreased signifi- cantly, which was significantly lower than that in control group （ 17.36±4. 57）（F= 30. 874, P = 0. 000） . Conclusion rTMS combined with CBT can effectively cure children with depression, which is worthy of clinical promotion.

作者冯虹秦国兴甘建光盖琼王铁锋

机构地区绍兴市第七人民医院

出处《中国妇幼保健》 CAS 2016年第12期2475-2478,共4页 Maternal and Child Health Care of China

基金浙江省医药卫生科技一般项目(2014KYB283)

关键词低频经颅磁刺激认知疗法儿童抑郁障碍疗效 Repetitive low-frequency transcranial magnetic stimulation Cognitive therapy Child with depression Curative effect

分类号 R749 [医药卫生—神经病学与精神病学]

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