阿奇霉素序贯疗法联合特步他林治疗小儿支原体肺炎临床研究

Clinical study on azithromycin sequential therapy combined with terbutaline in treatment of mycoplasma pneumonia in children

目的应用阿奇霉素序贯疗法联合特步他林治疗小儿支原体肺炎,观察其临床疗效及不良反应。方法随机选择2013年7月至2014年2月嘉兴市第一医院诊治的儿童支原体肺炎患者294例,随机分为研究组和对照组,每组147例。研究组患儿应用阿奇霉素序贯疗法联合特步他林治疗;对照组患儿给予阿奇霉素序贯疗法治疗。两个疗程后评估临床疗效,评估主要症状或体征消失时间、观察患儿不良反应。结果研究组患儿总有效率高于对照组的(P<0.05)。研究组体温恢复正常时间、咳喘消失时间、肺部啰音消失时间、X线肺部恢复正常时间及住院时间均低于对照组,两组比较,差异具有统计学意义(P<0.05)。结论应用阿奇霉素序贯疗法联合特步他林治疗小儿支原体肺炎,临床疗效显著提高,患儿症状(或体征)恢复或改善时间及住院时间明显缩短,且不良反应未出现增加,值得临床推广应用。

Objective To observe the clinical efficacy and adverse reactions of azithromycin sequential therapy combined with terbutal- ine in treatment of mycoplasma pneumonia in children. Methods A total of 294 children with mycoplasma pneumonia admitted in the First Hospital of Jiaxing City were randomly collected from July 2013 to February 2014. They were randomly divided into study group and control group, 147 cases in each group. In study group, the children underwent azithromycin sequential therapy combined with terbutaline; the chil- dren in control group underwent azithromycin sequential therapy, After two courses of treatment, the clinical efficacies in the two groups were evaluated, as well as the disappearance time of main symptoms or signs, and the adverse reactions were observed. Results The total effec- tive rate in study group was statistically significantly higher than that in control group （ P〈0. 05 ） . In study group, it took shorter time for the body temperature return to normal, disappearance of cough and pulmonary rales, X-ray of lung return to normal, and hospitalization, coma- pred with control group, the difference was statistically significant （ P〈0. 05） . Conclusion The clinical efficacy is significantly improved when azithromycin sequential therapy combined with terbutaline is used in treatment of children with mycoplasma pneumonia, which can shorten improvement or recovery time of children＇s symptoms （or signs） and hospitalization time without increase in adverse reactions. So it is worthy of clinical popularization and application.