摘要
目的观察寿胎丸加减方联合地屈孕酮治疗早期先兆流产合并绒毛膜下血肿疗效及血雌二醇、孕酮及人绒毛膜促性腺激素和Th1/Th2细胞因子的影响,以免疫-内分泌角度分析其作用机制。方法将60例患者随机分为两组,对照组单纯给予地屈孕酮,治疗组在对照组的基础上联合寿胎丸加减方进行治疗,分别于治疗前后一周、两周检测外周血中雌二醇、孕酮、人绒毛膜促性腺激素、Th1型细胞因子INF-γ和Th2型细胞因子IL-10,复查B超评估临床疗效。结果与对照组相比,治疗组的雌二醇、孕酮、人绒毛膜促性腺激素水平均明显升高(P<0.05),INF-γ水平降低(P<0.01),IL-10水平升高(P<0.01),Th1/Th2比值降低,偏向Th2(P<0.01);治疗组有效率为90.00%,显著高于对照组76.67%(P<0.05)。结论寿胎丸加减方联合地屈孕酮能有效调节Th1/Th2细胞因子,使之恢复平衡,并升高雌二醇、孕酮及人绒毛膜促性腺激素水平。
Objective To observe the effect of modified Shoutai pills combined with dydrogesterone in treatment of early threatened a- bortion complicated with subchorionic hematoma and impact on serum levels of estradiol, progesterone, β- human chorionic gonadotropin （β-HCG） and Th1/Th2 cytokines, analyze the immune-endocrine mechanisms. Methods Sixty patients were randomly divided into two groups. The patients in control group were treated by dydrogesterone, while the patients in treatment group were treated by modified Shoutai pills and dydrogesterone. At one and two weeks before and after treatment, the serum levels of estradiol, progesterone, and β-HCG, Thl cy- tokine interferon-γ （INF-γ） and Th2 cytokine interleukin-10 （IL-10） were detected in the two groups. Clinical efficacy was assessed u- sing type B ultrasonography. Results Compared with control group, the serum levels of estradiol, progesterone, and β-HCG significantly increased in treatment group （ P〈0. 05 ）, IFN-γ level significantly decreased （ P〈0. 01 ）, IL- 10 level significantly increased （ P〈0. 01 ）, Th1/Th2 ratio significantly decreased, moving to Th2 （P〈0. 01 ） . The total effective rate was 90. 00% in treatment group, which was sig- nificantly higher than that in control group （76. 67% ） （ P〈0. 05 ） . Conclusion Modified Shoutai pills combined with dydrogesterone can effectively regulate Thl/Th2 eytokines and maintain balance, which can increase estradiol, progesterone, and β-HCG levels.
出处
《中国妇幼保健》
CAS
2016年第12期2516-2518,共3页
Maternal and Child Health Care of China
基金
江西省卫生厅中医药科研基金课题(2013A062)
