外周血白细胞介素-25和-33表达与慢性自发性荨麻疹患者病情的相关性研究

Expression of interleukin-25 and interleukin-33 in peripheral blood of patients with chronic idiopathic urticaria: a correlation study

目的:探讨外周血中白细胞介素(IL)-25、IL-33的表达与慢性自发性荨麻疹患者病情严重程度的相关性。方法:慢性自发性荨麻疹患者75例,健康人对照30例,其中慢性自发性荨麻疹患者按病情分为轻、中、重3组。采用酶联免疫吸附试验检测外周血IL-25、IL-33水平,分析慢性自发性荨麻疹患者病情严重程度与IL-25、IL-33水平的相关性。结果:慢性自发性荨麻疹患者IL-25、IL-33水平分别为(149.58±25.47)ng/L、(95.41±25.59)ng/L,健康对照组分别为(120.52±28.16)ng/L、(80.25±25.03)ng/L,慢性自发性荨麻疹患者IL-25、IL-33水平较健康对照组显著升高(P<0.01和<0.05),且与患者病情呈正相关(r分别为O.54和0.67,均P<0.01)。结论:IL-25、IL-33在慢性自发性荨麻疹患者外周血中表达水平升高,并与症状严重程度呈正相关。

Objective： To evaluate the relationship of intedeukin-25 and intedeukin-33 with chronic idiopathic urticaria （CU）. Methods： Seventy-five patients with chronic idiopathic urticaria and 30 normal controls were included in this study. The patients with CU were classified into three groups according to the severity of clinical symptoms. Enzyme--linked im- munosorbent assay（ELISA） was performed to detect the serum levels of IL-25 and IL-33. The relationship between the ex- pression levels of these two eytokines and urticaria severity was analyzed. Results： The serum levels of IL-25 and IL-33 in the patients were significantly higher than that in the normal control（IL-25,149.58±25.47 vs. 120.52±28.16 ng/L, P〈0.01; IL- 33, 95.41±25.59 vs. 80.25±25.03 ng/L, P〈0.05）, and positively correlated with the severity of urticaria（r=0.54 and 0.67 re- spectively. P〈0.01 for both）. Conclusions： The expression levels of IL-25 and IL-33 in peripheral blood of patients with chronic idiopathic urticaria are elevated and positively correlated with the seveiity of urticaria.