新型无毒交联明胶微球的制备及性状研究

The preparation and trait study of gelatin microspheres by new non - toxic crosslinking technology

目的介绍一种新型无毒交联明胶微球的制备方法。方法通过无毒交联技术和纳米微通道切割技术制备明胶微球，随机取100个明胶微球为实验组和100个Embosphere微球为对照组，显微镜评价微球的形态和粒径。结果实验组明胶微球呈圆球状形态，粒径范围：30～1000μm，抽样粒径为（197．90±5．39）μm，粒径分布呈正态分布。对照组Embosphere微球粒径大小不均，粒径范围：100—700μm，抽样粒径为（200．40±12．73）μm，粒径分布近似正态分布。结论自主研发的纳米微通道切割技术先进、生产效率高，无毒交联明胶微球粒径均一。

Objective To introduce a new type of preparation of gelatin microspheres by new non- toxic crosslinked technique. Methods The gelatin microspheres were prepared by non -toxic crosslinking technology and nano micro - channel cutting technology. 100 gelatin microspheres were ran- domly selected as the experimental group, while 100 Embosphere mierospheres were selected as the control group. Under the microscope, the shape and diameter of gelatin microspheres was evaluated. Results The gelatin microspheres of the experimental group were spherical shape, and its particle size range from 30 μm to 1 000 μm. The sample particle size was（ 197. 90 ±5. 39） μm, and particle size distribution was normal. The gelatin microspheres of the control group were also spherical shape, and its particle size range from 100 μm to 700 μm. The sample particle size was（200.40 ± 12. 73） ixm, and particle size distribu- tion was approximately normal. Conclusion The independent development＇ s nano micro - channel cutting technology was advanced and the productivity of micrnspheres was high, and the particle size was uniform. However, this study has beed in the early stage, and it still need animal experiments which can test bin- compatibility and embolic effect.