利用自适应光学技术矫正角膜塑形镜配戴眼残余像差的研究

Research on Residual Aberrations Correction with Adaptive Optics Technique in Patients Undergoing Orthokeratology

本研究旨在利用自适应光学技术矫正角膜塑形镜（OK镜）配戴眼的残余像差，探讨其残余像差的变化对配戴眼对比敏感度功能的影响。共纳入19例受试对象的19只眼，年龄（14．27±2．23）岁（12—20岁）。运用自适应光学系统在4mm人工瞳孔直径下测量和矫正角膜塑形镜配戴眼的残余像差，同时测量五个空间频率（2，4，8，16和32cpd）下的对比敏感度值。研究对象配戴眼的残余像差矫正前后各测一次，两次测试的顺序随机。对比敏感度的测试采用二项迫选法。数据的测量完成后采用配对t检验比较残余像差矫正前后各个空间频率下的对比敏感度对数值。结果显示经自适应光学系统矫正后，平均总像差均方根值（RMS值）从0．356μm下降到0．160μm（t=10．517，P〈0．001），平均总高阶像差RMS值从0．246μm下降到0．095μm（t=10．113，P〈0．001）。矫正残余像差后的对比敏感度对数值与矫正前相比，差异仅在8cpd的空间频率下有统计学意义（t=-2．51，P=0．022）。因此本研究发现利用自适应光学技术矫正角膜塑形镜配戴眼的残余像差，可提高配戴眼中空间频率的对比敏感度功能。

We conducted this study to explore the influence of the ocular residual aberrations changes on contrast sensitivity （CS） function in eyes undergoing orthokeratology using adaptive optics technique. Nineteen subjects＇nineteen eyes were included in this study. The subjects were between 12 and 20 years （14.27±2.23 years） of age. An adaptive optics （AO） system was adopted to measure and compensate the residual aberrations through a 4-m artificial pupil, and at the same time the contrast sensitivities were measured at five spatial frequencies （2,4,8,16, and 32 cycles per degree）. The CS measurements with and without AO correction were completed. The sequence of the measurements with and without AO correction was randomly arranged without informing the observers. A two-interval forced-choice procedure was used for the CS measurements. The paired t-test was used to compare the contrast sensitivity with and without AO correction at each spatial frequency. The results revealed that the AO system decreased the mean total root mean square （RMS） from 0. 356 μ to 0. 160 μ（t=10. 517, P〈. 001）, and the mean total higher-order RMS from 0. 246 μ to 0. 095μ（t=10. 113, P〈. 001）. The difference in log contrast sensitivity with and without AO correction was significant only at 8 cpd （t= -2.51, P=0.02）. Thereby we concluded that correcting the ocular residual aberrations using adaptive optics technique could improve the contrast sensitivity function at intermediate spatial frequency in patients undergoing orthokeratology.