TP63相互作用蛋白分析

Bioinformatic Analysis of TP63-related Proteins

目的:分析先天缺牙和唇/腭裂综合征相关蛋白--TP63蛋白的相互作用分子,并对其生物学功能进行分析。方法:利用生物信息学数据库(STRING)分析和预测TP63蛋白的相互作用蛋白。在DAVID数据库对相互作用蛋白的生物学功能进行分析。结果:对STRING数据库预测的TP63蛋白50个相互作用蛋白的生物学功能分析显示,TP63相互作用分子主要参与对细胞增殖和凋亡的调节。结论:生物信息学分析初步揭示了TP63蛋白的相互作用网络及其生物学功能。

Objective：To analyze the interactive molecules of TP63 which is related to hypodontia and cleft lip/palate.Methods：The interactive molecules of TP63 were predicted by the STRING database.The molecular biology function was determined by the DAVID database.Results：The STRING database predicted 50 genes that correlated with TP63.Most of them were involved in the cell proliferation and apoptosis process.Conclusion：Bioinformatic analysis tentatively explored the interactive network of TP63 protein.