健康体检者代谢综合征与肾功能的相关性研究

Correlation between Metabolic Syndrome and Renal Function in Physical Examination Population:A Cross-sectional Study

目的 探讨健康体检者代谢综合征（MS）与肾功能之间的关系。方法 收集2015年3月~2015年4月在四川大学华西医院进行健康体检者的资料。计算其体重指数（BMI）和肾小球滤过率（GFR）,分析MS与肾功能的相关性。结果 共纳入10 098例体检者,其中MS患者1 110例（10.99%）。MS组患者的尿酸、胆固醇、尿素和肌酐指标明显高于非MS组,GFR水平明显低于非MS组（P均〈0.05）。肾功能降低组患者的收缩压、舒张压、空腹血糖、低密度脂蛋白胆固醇、总胆固醇、甘油三酯、尿酸指标均显著高于肾功能正常组,而高密度脂蛋白胆固醇显著低于肾功能正常组（P均〈0.01）。结论 BMI、血压、血糖及尿酸水平的升高加速GFR的下降,MS是肾功能损害的重要危险因素。

Objective To explore the correlation between metabolic syndrome and renal function in physical examination population. Methods The data of individual physical examination in West China Hospital from March to April 2015 was collected. Body mass index （BMI）, glomerular filtration rate （GFR） were calculated, and the correlation between metabolic syndrome and renal function was analyzed by using SPSS 16.0 software. Results A total of 10 098 individuals were included, of which 1110 were MS patients were included. The results of analysis showed that, the levels of uric acid, cholesterol, urea and creatinine in MS group were significantly higher than those in non-MS group, and the level of GFR was significantly lower than that in non-MS group （P〈0.05）. Renal function in patients with abnormal systolic blood pressure, diastolic blood pressure, fasting blood glucose （FBG）, low density lipoprotein, total cholesterol, triglycerides, uric acid index were significantly higher than those in normal renal function group, and high density lipoprotein cholesterol was significantly lower than that of normal renal function group （P〈0.01）. Conclusion Elevated levels of BMI, blood pressure, glucose, uric acid are correlated with the decrease of GFR, and metabolic syndrome is an important risk factor of renal dysfunction.