TM6SF2基因rs58542926多态性与肝细胞损伤和肝纤维化严重程度相关性的Meta分析

Association between the Polymorphism of the TM6SF2- rs58542926 Gene and Liver Damage and the Severity of Liver Fibrosis:A Meta-analysis

目的系统评价TM6SF2基因突变与肝细胞损伤及纤维化严重程度的相关性。方法计算机检索Pub Med、CNKI、Wan Fang Data和CBM数据库,搜集有关TM6SF2基因多态性与肝纤维化以及肝细胞损伤相关性的横断面研究,检索时限均为建库至2016年1月27。由两位研究者独立筛选文献、提取资料,并评价纳入研究的方法学质量后,采用Stata 12.0软件进行Meta分析。结果最终纳入23个研究,共96 594例患者。Meta分析结果显示,在显性模型中,TM6SF2基因的变异与肝纤维化的严重程度,以及甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白(LDL-C)水平具有显著相关性(P均<0.05)。T的携带者与C的纯合子个体相比较,其TC、TG、LDL-C的水平较低,而ALT、AST的水平较高。结论 TM6SF2的基因变异与不同人群脂质形成及代谢密切相关,突变型个体血脂含量水平较低,发生严重肝纤维化及肝损伤的风险更大。

Objectives To systematically review the association between TM6SF2 （transmembrane six superfamily member 2- rs58592426） polymorphism and liver lesion and the severity of liver fibrosis. Methods We electronically searched databases including PubMed, CNKI, WanFang Data and CBM from inception to January 27, 2016, to collect cross-sectional studies about the association between the TM6SF2 polymorphism and the liver lesion and the severity of liver fibrosis. Two reviewers independently screened literature, extracted data and assessed the methodological quality included studies. Then, meta-analysis was performed using Stata 12.0 software. Results A total of 23 studies including 96 594 patients were included. The results of meta-analysis showed that： TM6SF2 polymorphism was associated with increased risk of the severity of liver fibrosis, the levels of TG, TC and LDL-C （all P values 〈0.05）. Carriers of the T allele showed lower levels ofTG, TC, and LDL-C. Carriers of the T allele revealed higher levels of alanine aminotransferase （ALT） and aspartate aminotransferase （AST） when compared with homozygous EE. Conclusion TM6SF2 polymorphism is associated with lipid traits in different population, the variants shows lower levels of lipid traits in blood serum and increases the risk of the severity of liver fibrosis and liver lesion.