真武汤加味对老年舒张性心力衰竭BNP、ET-1、CRP的影响

Effect of Zhenwu Tang on BNP,ET-1 and CRP of Elderly Patients with Diastolic Heart Failure

目的:探讨真武汤加味干预对老年舒张性心力衰竭(DHF)患者血浆脑钠肽(BNP)、内皮素-1(ET-1)、C-反应蛋白(CRP)水平的影响。方法:将120例患者随机分为2组各60例。对照组给予西医常规治疗;治疗组在对照组治疗基础上加用中药免煎颗粒真武汤加味治疗。治疗4周。结果:治疗前2组BNP、ET-1、CRP比较,差异无统计学意义(P>0.05)。治疗4周后2组BNP、ET-1、CRP均有下降,与本组治疗前比较,差异有统计学意义(P<0.01);治疗后治疗组BNP、ET-1、CRP水平较对照组下降更明显,与对照组比较,差异有统计学意义(P<0.01)。结论:真武汤加味治疗老年DHF患者可能与减少水钠潴留、改善内皮功能、降低炎性反应有关。

Objective： To discuss the effect of Zhenwu tang on the level of brain natriuretic peptide（BNP）, endothelin- 1（ET- 1） and C- reactive Protein（CRP） of elderly patients with diastolic heart failure（DHF）. Methods：One hundred and twenty cases of patients were divided into 2 groups randomly,60 cases in each group. The patients in the control group were given conventional western therapy. The boil- free granule of Zhenwu tang was added in the treatment group on the basis of treatment in the control group. The treatment course is 4 weeks. Results：The difference of the levels of BNP,ET- 1 and CRP in both groups before and after treatment was no statistical significant（P〉0.05）.After treatment of 4 weeks,the levels of BNP、ET- 1and CRP of two groups were all dropped（P〈0.01 compared with before treatment）. After treatment,the dropping of the levels of BNP、ET- 1 and CRP in the treatment group was more obvious than that in the control group（P〈0.01）. Conclusion：The treatment of Zhenwu tang on elderly patients with DHF may be associated with the reduction of sodium and water retention,the improvement of endothelial function and the reduction of the inflammatory reaction.