牙周炎与代谢综合征的相关性及西帕依固龈液疗效观察

Correlation between Periodontitis and Metabolic Syndrome and Therapeutic Observation on Xipayi Mouth Rinse

目的:观察牙周炎与代谢综合征的相关性,并观察西帕依固龈液干预对牙周炎患者脂联素以及炎症因子的影响。方法:纳入156例牙周炎患者,并分成西帕依固龈液组48例、西药组62例和空白含漱液组46例,将30名健康成年人设为正常对照组。西帕依固龈液组采用西帕依固龈液治疗,西药组口服甲硝唑片治疗,空白含漱液组只用清水含漱。3组均进行牙周检查,观察各组的脂联素和炎症因子水平。结果:代谢综合征指标收缩压(SBP)、空腹血糖(FPG)、血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)均是影响牙周炎发生的重要因素。干预3月后,空白含漱液组牙周检查各指标与干预前比较,差异均无统计学意义(P>0.05);西帕依固龈液组各指标植均较干预前下降(P<0.05)并均低于空白含漱液组、西药组(P<0.05)。干预3月后,西帕依固龈液组和西药组的脂联素水平均较治疗前上升(P<0.05),而C-反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)均较治疗前下降(P<0.05);西帕依固龈液组脂联素水平较其他2组上升,炎症因子较其他2组下降,差异均有统计学意义(P<0.05),而与正常对照组比较,差异均无统计学意义(P>0.05)。结论:代谢综合征指标与牙周炎发生具有密切相关性,西帕依固龈液干预可以改善牙周炎患者的脂联素与炎症因子水平,有利于牙周炎的炎症控制。

Objective： To observe the correlation between periodontitis and metabolic syndrome and the effect of Xipayi mouth rinse on the adiponectin and inflammatory factor of patients with periodontitis. Methods：One hundred and fifty- six cases of patients with periodontitis were divided into three groups with 48 cases in Xipayi mouth rinse group,62 cases in western medicine group and 46 cases in blank mouth rinse group. Thirty cases of healthy adults were set as normal control group. Patients in Xipayi mouth rinse group were given Xipayi mouth rinse treatment. Patients in western medicine group received orally metronidazole tablets. Patients in blank mouth rinse group just washed the mouth with clean water. Patients in three groups all took the periodontal examination to observe the levels of adiponectin and inflammatory factor. Results：Metabolic syndrome such as systolic blood pressure（SBP）, fasting blood glucose（FBG）, serum total cholesterol（TC）,triglyceride（TG）, high density lipoprotein cholesterol（HDL- C） and low density lipoprotein cholesterol（LDL- C） were all key factors on the paroxysm of the periodontitis. After treatment for 3 months,the indexes in blank mouth rinse group were no significant change（P〈0.05）. Comparing each index between blank mouth rinse group and Xipayi mouth rinse group, the differences were significant（P0.05）. After treatment for 3 months,the adiponectin in blank mouth rinse group and Xipayi mouth rinse group were all increased（P〈0.05）, while the levels of C- reactive Protein（CRP）, tumor necrosis factor- α（TNF- α）,and interleukin- 6（IL- 6）were all dropped（P0.05）. Comparing with those in other group,the adiponectin level in Xipayi mouth rinse group was increased obviously,while the inflammatory factor was dropped obviously,differences being significant（P〈0.05）. However, comparing with those in normal control group, difference was no significant（P〈0.05）.Conclusion：The metabolic syndrome index has a close correlation with the paroxysm of periodontitis. The therapy with Xipayi mouth rinse can improve the level of adiponectin and inflammatory factor, which benefits to the inflammation control of periodontitis.