TCT联合HPV检测在宫颈病变筛查中的临床价值

Clinical value analysis of TCT combined with HPV detection on screen cervical lesions

目的对宫颈液基细胞学检查（TCT）联合人乳头状瘤病毒检测（HPV）在宫颈病变筛查中的临床价值进行探讨。方法回顾性分析2013年7月至2015年7月进行TCT和HPV检测的宫颈病变患者1180例，以组织学为金标准对TCT、HPV及TCT联合HPV检测结果进行分析。结果TCT检查敏感度为75．85％，特异度为33．10％；HPV检查敏感度为79．88％，特异度为39．31％；TCT联合HPV检查敏感度为99．00％，特异度为100％。结论TCT联合HPV检查可以提高宫颈病变的检出率，避免低风险人群的过度阴道镜活检及过度治疗。

Objective To investigate the clinical value of thinprep cytologic test （TCT） combined with human papillomavirus（HPV） detection on screen cervical lesions. Methods From July 2013 to July 2015, the clinical data of 1180 patients having TCT combined with HPV detection were retrospectively analyzed. Histology was used as the gold standard to analyze the TCT, HPV and TCT joint HPV testing results. Results The sensitivity of TCT inspection was 75.85%, specificity was 33.10% ; sensitivity of HPV examination was 79. 88%, specificity was 39.31% ; sensitivity of TCT joint HPV examination was 99.00%, specificity was 100%. Conclusions TCT combined with HPV examination can improve the detection rate of cervical lesions, which could also avoid excessive colposcopy biopsy and excessive treatment with low risk.