活血荣络片对脑梗死阴虚血瘀证二级预防的临床观察

Clinical effect of Huoxue Rongluo tablets in secondary prevention of yin-deficiency and blood- stasis syndrome in patients with cerebral infarction

目的:探讨活血荣络片对脑梗死阴虚血瘀证患者二级预防的临床疗效。方法:选取72例脑梗死患者,随机分为对照组和治疗组各36例。对照组予阿司匹林肠溶片预防,治疗组予活血荣络片预防。观察两组临床疗效、治疗期间严重心脑血管事件(ACCE)发生率,入院时和第24周CSS评分、日常生活能力(ADL)评分、中医证候积分以及入院时、第12周、第24周患者血浆血小板聚集率、血浆CD62p表达率。结果:总有效率、ACCE发生率治疗组分别为92.7%、11.1%,对照组分别为94.4%、13.9%,组间比较,差异均无统计学意义(P<0.05)。两组CSS评分、ADL评分及中医证候积分治疗24周时与入院时组内比较,差异有统计学意义(P<0.05);组间比较,差异亦有统计学意义(P<0.05)。两组血浆血小板聚集率、血浆CD62p表达率在第12周时、第24周时分别与入院时组内比较,差异有统计学意义(P<0.05);组间比较,差异无统计学意义(P>0.05)。结论:在阴虚血瘀证脑梗死二级预防中,活血荣络片与阿司匹林肠溶片的临床疗效相当,能改善中医临床症状和促进病情恢复,提高患者生活质量。

Objective： To investigate the clinical effect of Huoxue Rongluo tablets in the secondary prevention of yin- deficiency and blood- stasis syndrome in patients with cerebral infarction. Methods： A total of 72 patients with cerebral infarction were enrolled and randomly divided into control group and treatment group,with 36 patients in each group. The patients in the control group were given aspirin enteric- coated tablets as preventive treatment,and those in the treatment group were given Huoxue Rongluo tablets. The clinical effect,incidence of acute cardiovascular and cerebrovascular event（ ACCE） during treatment,cancer- specific survival（ CSS） score on admission and at week 24 of treatment,activities of daily living（ ADL） score,traditional Chinese medicine（ TCM） syndrome score,and platelet aggregation rate and expression of plasma CD62 p on admission and at weeks 12 and 24 of treatment. Results： The overall response rate and incidence rate of ACCE showed no significant differences between the treatment group and the control group（ overall response rate： 92. 7% vs94. 4%,P〉0. 05; incidence rate of ACCE： 11. 1% vs13. 9%,P〉0. 05）. The two groups showed significant improvements in CSS score,ADL score,and TCM syndrome score at week 24 of treatment（ P〈0. 05）,and these scores showed significant differences between the two groups（ P〈0. 05）. The platelet aggregation rate and expression of plasma CD62 p were significantly improved at weeks 12 and 24 of treatment（ P〈0. 05）,but showed no significant differences between the two groups（ P〉0. 05）. Conclusion： In the secondary prevention of yin- deficiency and blood- stasis syndrome in patients with cerebral infarction,Huoxue Rongluo tablets have a comparable clinical effect to aspirin enteric- coated tablets and can improve TCM clinical symptoms,promote recovery,and improve patients＇ quality of life.