含苯硼酸官能团纤维素膜的制备及性能

Preparation and Properties of the Cellulose Membrane Containing Phenylboronic Acid Functional Groups

采用2,2,6,6-四甲基哌啶-1-氧基(TEMPO)/Na Br/Na Cl O氧化体系将纤维素膜C6位上的羟基氧化为羧基,再利用水溶性偶合试剂N-(3-二甲氨基丙基)-N'-乙基碳二亚胺盐酸盐(EDC)和N-羟基琥珀酰亚胺(NHS)将3-氨基苯硼酸与氧化纤维素膜以形成酰胺键的方式结合起来,从而制备出接枝有苯硼酸官能团的纤维素膜。文中对苯硼酸改性纤维素膜进行了结构表征与力学性能检测,并对改性过程中各因素的影响进行了讨论。结果表明,当TEMPO的用量为0.005 g,Na Br的用量为0.025 g,10%的Na Cl O溶液的用量为4 m L及氧化时间控制在60 min以内时,可以获得力学强度较好的纤维素膜。此外,该膜对含有多醇结构微粒的吸附与解吸过程可通过p H值控制来实现。鉴于苯硼酸结构对多醇类化合物具有的探针作用,所制得的改性纤维素膜在快速方便检测糖尿病等方面具有潜在的应用价值。

The 2,2,6,6-tetramethylpiperidine 1-oxyl radical（ TEMPO） / Na Br / Na Cl O oxidation method was applied to oxidize C6 hydroxyl groups on cellulose into carboxyl groups. Subsequently,water-soluble coupling reagent EDC and NHS were used to graft 3-aminobenzeneboronic acid onto the oxidized cellulose membrane with generating amide bond to prepare modified cellulose membrane containing phenylboronic acid functional groups. The structure and mechanical properties of the modified cellulose membrane were characterized. The influence factors during the modification process were also discussed. The results show that satisfactory mechanical strength of the modified cellulose membrane could be obtained while the dosage of TEMPO,Na Br,10% Na Cl O solution is 0. 005 g,0. 025 g and 4 mL respectively and the oxidation time should be less than 60 min. In addition,the adsorption and desorption of polyol containing particles onto the modified membrane are achieved by p H control. Because the structure of phenylboronic acid bears the ability to probe polyol compounds,the modified cellulose membrane is provided with potential applications in some areas such as fast and convenient detection of diabetes.