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滤泡辅助性T细胞及其与系统性红斑狼疮关系的研究进展

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摘要 滤泡辅助性T细胞(Th)是近年来发现的辅助B细胞发生体液免疫的一类新的CD4+T细胞亚群,其具有特异的细胞识别表位(CD4+CXCR5+)和主要的信号传导分子(BCL-6、诱导性协同共刺激分子、程序性细胞死亡蛋白-1),并能分泌一系列细胞因子[白细胞介素(IL)-21、IL-6、IL-27等]。Th在B细胞的发育、分化,抗体的产生和类型转换以及生发中心的形成中发挥重要作用。Th细胞数量及其效应分子的异常与多种自身免疫性疾病密切相关,系统性红斑狼疮(SLE)是一种发病率较高的典型的自身免疫性疾病。该文主要综述了Th细胞的特征、功能、分化发育及其与SLE的关系,深入研究Th细胞可能为治疗SLE发现新的治疗靶点和方向。
作者 赵娟 李立新 武永康
机构地区 四川大学华西医院实验医学科
出处 《华西医学》 CAS 2016年第6期1142-1146,共5页 West China Medical Journal
基金 四川省科技厅基金项目(2016JY0035)
关键词 滤泡辅助性T细胞 系统性红斑狼疮 发病机制 治疗
分类号 R593.241 [医药卫生—内科学]
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参考文献52

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华西医学
2016年 第6期

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