胃底腺息肉与Hp感染及抑酸剂关系分析

Relationship between gastric fundus gland polyps and Helicobacter pylori infection and acid inhibitor

目的 探讨胃底腺息肉与幽门螺杆菌（Hp）感染情况以及使用质子泵抑制剂的关系.方法 选择2012年1月至2014年1月在我院接受治疗的胃底腺息肉病患者89例为观察组.再选择同期进行检查的浅表性胃炎患者50例为对照组.首先对观察组的腺息肉发生情况进行统计,然后与对照组对比Hp感染、服用质子泵抑制剂、H2受体阻滞剂、胃黏膜保护剂情况.另再选择50例胃腺癌病患者（胃腺癌组）作3组的Ki-67抗原检查进行比较分析.结果 胃底腺息肉发生情况：在胃底34.83％（31/89）、胃体43.82％ （39/89）发生的比例相对更高,贲门12.36％（11/89）、胃窦8.99％ （8/89）次之,差异有统计学意义（x2=5.192,P=0.001）,并且多以单发形式出现,占65.17％（58/89）.观察组Hp感染率为50.56％ （45/89）,与对照组的54.00％（27/59）比较差异无统计学意义（x2=0.152,P=0.697）,并且观察组Hp感染强度多集中在中低轻度,而对照组以中高强度为主.Ki-67抗原检查比较,胃腺癌组中的表达82.00％（41/50）显著高于观察组23.60％（21/89）,差异均有统计学意义（x2=44.196,P=0.000）.结论 Hp感染以及长期服用质子泵抑制剂、H2受体阻滞剂、胃黏膜保护剂均不是构成胃底腺息肉的危险因素.并且胃底腺息肉处于良性病变状态,不具有恶化的趋势.

Objective To investigate the relationship among infection of the gastric fundus gland polyps and Hp,and the use of proton pump inhibitors（PPI）.Methods From January 2012 to January 2014,89 cases of gastric fundus gland polyps who were treated in the First Central Hospital of Baoding were selected as the observation group.Fifty cases of the same period for the examination of the superficial gastritis were selected as the control group.First,the occurrence of glandular polyps in the observation group was counted statistically,and then Hp infection,taking PPI,H2RA and gastric mucosal protective agent were compared with control group.Another 50 cases of gastric cancer patients were selected,then the Ki-67 antigen test was used for contrast analysis among the three groups.Results The occurrence proportion of undic gland polyps occurred in fundic,gastric body,cardiac and gastric antrum were 34.83% （31/89）,43.82% （39/89）,12.36% （11/89） and 8.99%（8/89） respectively,the difference was significant （x2=5.192,P=0.001）,and more in the form of a single appearance,accounting for 65.17%（58/89）.The Hp infection rate of the observation group was 50.56% （45/89）,compared with 54.00% （27/59） of control group,the difference was not statistically significant （x2=0.152,P=0.697）,and the Hp infection intensity of observation group concentrated in the low and mild,while in the control group,the high intensity was the main.Ki-67 antigen test comparison showed that expression in the gastric cancer group was 82.00% （41/50）,significantly higher than that of the observation group（23.60% （21/89））,the difference was statistically significant（x2=44.196,P=0.000）.Conclusion Hp infection and long-term administration of PPI,H2RA,gastric mucosal protective agent are not the risk factors of gastric gland polyps.And the gastric fundus gland polyps are in the benign disease condition,do not have the deterioration tendency.