肌萎缩侧索硬化症患者血清及脑脊液中白介素-17水平变化

Analysis of Cerebrospinal Fluid and Serum IL-17 Levels in Patients with Amyotrophic Lateral Sclerosis

目的测定肌萎缩侧索硬化症(amyotrophic lateral sclerosis,ALS)患者血清及脑脊液中白介素-17(interleukin-17,IL-17)水平来研究血清及脑脊液中IL-17水平是否与ALS疾病进展率有相关性。方法所有受试者采集血清样本,对27例ALS患者与16例对照组患有紧张性头痛患者采集脑脊液样本,用酶联免疫吸附试验测定IL-17水平。结果 ALS患者血清及脑脊液中IL-17水平较对照组显著升高。且脑脊液中IL-17水平与疾病进展率(DPR)有显著相关性。结论 IL-17作为促炎因子,它可能作为生物标记物在ALS发病及预后评估中起重要作用。

Objective To analyze the cerebrospinal fluid （CSF） and serum IL- 17 levels in patients with amyotrophie lateral sclerosis （ALS）, and to investigate whether IL - 17 has a correlation with disease progression rate（DPR）. Methods All the participants enrolled was collected serum samples. Of all the ALS patients, twenty - seven patients and sixteen patients with tension - type - headache in the control subjects were performed lumbar punctures in a standardize way~ CSF and blood samples were collected. The levels of IL - 17 were performed by the enzyme - linked immunosorbent method using commercial ELISA assay. Results IL - 17 levels were found to increase significantly in CSF and serum in ALS patients studied, moreover, IL - 17 levels in CSF were positively and significantly correlated with DPR of ALS. Con- dusion IL - 17, as a proinflammatory, could be a useful biomarker in the prognostic and evaluating potential for ALS.