老年男性2型糖尿病患者血浆Hcy的表达水平与骨密度的相关性分析

Association between plasma Hcy and bone mineral density in elderly male patients with type 2 diabetes mellitus

目的:探讨血浆同型半胱氨酸(Hcy)与老年男性2型糖尿病患者骨密度(BMD)的关系。方法:收集老年男性2型糖尿病患者45例,根据BMD水平分为骨量减少组(A组,24例)、骨量正常组(B组,21例)。检测各组患者的血浆Hcy水平、体质量指数(BMI)、血钙、血磷、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)及高密度脂蛋白胆固醇(HDL-C),2组之间进行比较。结果:A组的BMD和BMI明显低于B组,差异有统计学意义(P<0.05);A组的Hcy明显高于B组,差异有统计学意义(P<0.05);2组的血钙、血磷、TC、TG、LDL-C及HDL-C比较差异均无统计学意义(P>0.05);Pearson相关性分析显示,BMD与BMI呈正相关(r=0.26,P<0.05),与Hcy呈负相关(r=-0.579,P<0.05)。结论:BMI下降、血浆Hcy水平升高可能与老年男性2型糖尿病患者BMD的降低相关。

Objective： To investigate the correlation between plasma Hcy and bone mineral density （BMD）in elderly male patients with type 2 diabetes mellitus （T2DM）. Methods： Forty-five elderly male patients with T2DM were divided into osteopenia group （group A, 24 patients） and normal group （group B, 21 patients） ac- cording to the level of BMD. Correlations between Hcy, body mass index （BMI）, blood calcium, blood phos- phorus, total cholesterol （TC）, triglyceride （TG）, high density lipoprotein cholesterol （HDL-C） and low density lipoprotein cholesterol （LDL-C） were analyzed in group A and groupB. Results： BMD and BMI in group A were significantly lower than those in group B （P〈0.05）. Hcy in group A was significantly higher than that in group B （P〈0.05）. Blood calcium, blood phosphorus, TC, TG, HDL-C and LDL-C had no statistically significant differ- ence between two groups （/〉〉0.05）. Pearson correlation analysis showed that BMD was positively correlated with BMI （r=0.26, P〈0.05）, and negatively correlated with Hcy （r=-0.579, P〈0.05）. Conclusion： The decline of BMI and incline of plasma Hcy may associate with decreasement of BMD in elderly male patients with T2DM.